CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038536
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 
Protein Synonyms/Alias
  
Gene Name
 Plod2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
153PDKRLADKYPVVHIGacetylation[1]
725CSIESPRKGWSFMHPacetylation[2]
725CSIESPRKGWSFMHPsuccinylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 758 AA 
Protein Sequence
MGDRGARPGR LMPMLALLSW AAGLGVAEET PGRIPADKLL VITVATKEND GFHRFMNSAK 60
YFNYTVKVLG QGQEWRGGDG MNSIGGGQKV RLLKEAMEHY ASQEDLVILF TECFDVVFAG 120
GPEEVLKKFQ KTNHKIVFAA DGLLWPDKRL ADKYPVVHIG KRYLNSGGFI GYAPYISRLV 180
QQWNLQDNDD DQLFYTKVYI DPLKREAFNI TLDHKCKIFQ ALNGATDEVV LKFENGKSRV 240
KNTFYETLPV AINGNGPTKI LLNYFGNYVP NSWTQENGCA LCDVDTIDLS TVDVPPKVTL 300
GVFIEQPTPF LPRFLNLLLT LDYPKEALQL FIHNKEVYHE KDIKVFVDKA KHDISSIKIV 360
GPEENLSQAE ARNMGMDFCR QDEKCDYYFS VDADVVLTNP RTLKFLIEQN RKIIAPLVTR 420
HGKLWSNFWG ALSPDGYYAR SEDYVDIVQG NRVGIWNVPY MANVYLIQGK TLRSEMNERN 480
YFVRDKLDPD MALCRNARDM TLQREKDSPT PETFQMLSPP KGVFMYISNR HEFGRLISTA 540
NYNTSHLNND FWQIFENPVD WKEKYINRDY SKIFTENIVE QPCPDVFWFP IFSERACDEL 600
VEEMEHYGKW SGGKHHDSRI SGGYENVPTD DIHMKQIGLE NVWLHFIREF IAPVTLKVFA 660
GYYTKGFALL NFVVKYSPER QRSLRPHHDA STFTINIALN NVGEDFQGGG CKFLRYNCSI 720
ESPRKGWSFM HPGRLTHLHE GLPVKNGTRY IAVSFIDP 758 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
 GO:0008475; F:procollagen-lysine 5-dioxygenase activity; IEA:InterPro.
 GO:0001666; P:response to hypoxia; IEA:Compara. 
Interpro
 IPR005123; Oxoglu/Fe-dep_dioxygenase.
 IPR006620; Pro_4_hyd_alph.
 IPR001006; Procol_lys_dOase. 
Pfam
 PF03171; 2OG-FeII_Oxy 
SMART
 SM00702; P4Hc 
PROSITE
 PS51471; FE2OG_OXY
 PS01325; LYS_HYDROXYLASE 
PRINTS