CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002717
UniProt Accession
Genbank Protein ID
 X05111 
Genbank Nucleotide ID
Protein Name
 T-cell surface antigen CD2 
Protein Synonyms/Alias
 LFA-2; LFA-3 receptor; OX-34 antigen; T-cell surface antigen T11/Leu-5; CD2 
Gene Name
 Cd2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
155ELKLYQGKEHLRSLRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function. 
Sequence Annotation
 DOMAIN 23 121 Ig-like V-type.
 DOMAIN 122 202 Ig-like C2-type.
 CARBOHYD 99 99 N-linked (GlcNAc...).
 CARBOHYD 106 106 N-linked (GlcNAc...).
 CARBOHYD 134 134 N-linked (GlcNAc...).
 DISULFID 132 196
 DISULFID 139 179  
Keyword
 3D-structure; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 344 AA 
Protein Sequence
MRCKFLGSFF LLFSLSSKGA DCRDSGTVWG ALGHGINLNI PNFQMTDDID EVRWERGSTL 60
VAEFKRKMKP FLKSGAFEIL ANGDLKIKNL TRDDSGTYNV TVYSTNGTRI LDKALDLRIL 120
EMVSKPMIYW ECSNATLTCE VLEGTDVELK LYQGKEHLRS LRQKTMSYQW TNLRAPFKCK 180
AVNRVSQESE MEVVNCPEKG LPLYLIVGVS AGGLLLVFFG ALFIFCICKR KKRNRRRKGE 240
ELEIKASRMS TVERGPKPHS TQASAPASQN PVASQAPPPP GHHLQTPGHR PLPPSHRNRE 300
HQPKKRPPPS GTQVHQQKGP PLPRPRVQPK PPCGSGDVSL PPPN 344 
Gene Ontology
 GO:0009986; C:cell surface; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0003823; F:antigen binding; IMP:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0043621; F:protein self-association; IDA:RGD.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0016337; P:cell-cell adhesion; IMP:RGD.
 GO:0042110; P:T cell activation; IMP:RGD. 
Interpro
 IPR013783; Ig-like_fold.
 IPR008424; Ig_C2-set.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set.
 IPR015631; SLAM_fam_rcpts.
 IPR015632; T-cell_sdhesion_molc_CD2. 
Pfam
 PF05790; C2-set
 PF07686; V-set 
SMART
 SM00409; IG 
PROSITE
 PS50835; IG_LIKE 
PRINTS
 PR01870; CD2ANTIGEN.