CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017484
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ADP-ribosylation factor GTPase-activating protein 1 
Protein Synonyms/Alias
 ARF GAP 1; ADP-ribosylation factor 1 GTPase-activating protein; ARF1 GAP; ARF1-directed GTPase-activating protein 
Gene Name
 ARFGAP1 
Gene Synonyms/Alias
 ARF1GAP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
102PCWSLQEKYNSRAAAubiquitination[1]
162SVTASSDKAFEDWLNubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). 
Sequence Annotation
 DOMAIN 7 124 Arf-GAP.
 ZN_FING 22 45 C4-type.
 MOD_RES 135 135 Phosphothreonine.
 MOD_RES 189 189 Phosphothreonine.
 MOD_RES 231 231 N6-acetyllysine.
 MOD_RES 304 304 Phosphoserine.
 MOD_RES 343 343 Phosphoserine (By similarity).
 MOD_RES 345 345 Phosphoserine (By similarity).
 MOD_RES 348 348 Phosphoserine (By similarity).
 MOD_RES 361 361 Phosphoserine (By similarity).  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; ER-Golgi transport; Golgi apparatus; GTPase activation; Metal-binding; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 406 AA 
Protein Sequence
MASPRTRKVL KEVRVQDENN VCFECGAFNP QWVSVTYGIW ICLECSGRHR GLGVHLSFVR 60
SVTMDKWKDI ELEKMKAGGN AKFREFLESQ EDYDPCWSLQ EKYNSRAAAL FRDKVVALAE 120
GREWSLESSP AQNWTPPQPR TLPSMVHRVS GQPQSVTASS DKAFEDWLND DLGSYQGAQG 180
NRYVGFGNTP PPQKKEDDFL NNAMSSLYSG WSSFTTGASR FASAAKEGAT KFGSQASQKF 240
WGHKQQPEPA SELGHSLNEN VLKPAQEKVK EGKIFDDVSS GVSQLASKGV GSKGWRDVTT 300
FFSGKAEGPL DSPSEGHSYQ NSGLDHFQNS NIDQSFWETF GSAEPTKTRK SPSSDSWTCA 360
DTSTERRSSD SWEVWGSAST NRNSNSDGGE GGEGTKKAVP PAVPTDDGWD NQNW 414 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0030660; C:Golgi-associated vesicle membrane; TAS:Reactome.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0048205; P:COPI coating of Golgi vesicle; TAS:Reactome.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; TAS:Reactome. 
Interpro
 IPR001164; ArfGAP. 
Pfam
 PF01412; ArfGap 
SMART
 SM00105; ArfGap 
PROSITE
 PS50115; ARFGAP 
PRINTS
 PR00405; REVINTRACTNG.