UniProt Accession

 TEBP_RAT; P83868 

Genbank Protein ID

 CK475788 

Genbank Nucleotide ID

  

Protein Name

 Prostaglandin E synthase 3 

Protein Synonyms/Alias

 Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23 

Gene Name

 Ptges3 

Gene Synonyms/Alias

 Tebp 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
7	*MQPASAKWYDRRDY	acetylation	[1]
33	DVNVNFEKSKLTFSC	acetylation	[1]
33	DVNVNFEKSKLTFSC	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (By similarity). 

Sequence Annotation

 DOMAIN 1 90 CS.
 MOD_RES 33 33 N6-acetyllysine (By similarity).
 MOD_RES 113 113 Phosphoserine.
 MOD_RES 118 118 Phosphoserine (By similarity).
 MOD_RES 148 148 Phosphoserine (By similarity).
 MOD_RES 151 151 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid biosynthesis; Fatty acid metabolism; Isomerase; Lipid biosynthesis; Lipid metabolism; Phosphoprotein; Prostaglandin biosynthesis; Prostaglandin metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 160 AA 

Protein Sequence

Gene Ontology

 GO:0005884; C:actin filament; IDA:RGD.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0051879; F:Hsp90 protein binding; IDA:RGD.
 GO:0002039; F:p53 binding; IDA:RGD.
 GO:0050220; F:prostaglandin-E synthase activity; ISS:UniProtKB.
 GO:0051082; F:unfolded protein binding; ISS:UniProtKB.
 GO:0060548; P:negative regulation of cell death; IMP:RGD.
 GO:0010628; P:positive regulation of gene expression; IMP:RGD.
 GO:0001516; P:prostaglandin biosynthetic process; ISS:UniProtKB.
 GO:0019233; P:sensory perception of pain; IMP:RGD. 

Interpro

 IPR007052; CS-like_domain.
 IPR017447; CS_domain.
 IPR008978; HSP20-like_chaperone. 

Pfam

 PF04969; CS 

SMART

  

PROSITE

 PS51203; CS 

PRINTS