UniProt Accession

 G3V3M6_HUMAN; G3V3M6 

Genbank Protein ID

 AL355075 

Genbank Nucleotide ID

  

Protein Name

 DNA-(apurinic or apyrimidinic site) lyase 

Protein Synonyms/Alias

  

Gene Name

 APEX1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
197	EAFRKFLKGLASRKP	ubiquitination	[1, 2]
228	RNPKGNKKNAGFTPQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 263 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004521; F:endoribonuclease activity; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0045454; P:cell redox homeostasis; IEA:Compara.
 GO:0071320; P:cellular response to cAMP; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0071375; P:cellular response to peptide hormone stimulus; IEA:Compara.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0014912; P:negative regulation of smooth muscle cell migration; IEA:Compara.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0042493; P:response to drug; IEA:Compara. 

Interpro

 IPR020847; AP_endonuclease_F1_BS.
 IPR005135; Endo/exonuclease/phosphatase.
 IPR004808; ExoDNase_III. 

Pfam

 PF03372; Exo_endo_phos 

SMART

  

PROSITE

 PS00726; AP_NUCLEASE_F1_1
 PS51435; AP_NUCLEASE_F1_4 

PRINTS