CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016475
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dedicator of cytokinesis protein 9 
Protein Synonyms/Alias
 Cdc42 guanine nucleotide exchange factor zizimin-1 
Gene Name
 Dock9 
Gene Synonyms/Alias
 D14Wsu89e; Kiaa1058 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
2079ANYREMAKELSDIMRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation (By similarity). 
Sequence Annotation
 DOMAIN 185 292 PH.
 DOMAIN 649 827 DHR-1.
 DOMAIN 1614 2055 DHR-2.
 MOD_RES 936 936 Phosphoserine.
 MOD_RES 1244 1244 Phosphoserine (By similarity).
 MOD_RES 1250 1250 Phosphothreonine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2055 AA 
Protein Sequence
MGCTTSVILF KGIRTVFERN CAYMCKQPGE SNALEYTAYN WSKEDSELSI AFCLAKPKLI 60
EPLDYENVIV QKKTQILNDC LREMLLFPYD DFQTAILRRQ GRYLRSTVPA NAEEEAQSLF 120
VTECIKTYNS DWHLVTYKYE DYSGEFRQLP NKVPKLDKLP VHVYEVDEEA DKDEDAASLG 180
SQKGGITKHG WLYKGNMNSA ISVTMRSFKR RFFHLIQLGD GSYNLNFYKD EKISKEPKGS 240
IFLDSCMGVI QNNRVRRFAF ELKMQDKSSY LLAADSEAEM EEWVTVLNKI LQLNFEAAMQ 300
EKRNGDPHED DEQSKLEGSG SGLDSYLPEL AKSTREAEIK LKSESRVKLF YLDPDTQKLD 360
FSSAEPEVKP FEEKFGKRIL VKCNDLSFNL QCCVAENEEG PTTNVEPFFV TLSLFDIKYN 420
RKISADFHVD LNHFSVRQML APTSPALMNG GQSPPAFQDA LHTAMQYPKQ GIFSVTCPHP 480
DIFLVARIEK VLQGSITHCA EPYMRSSDSS KVAQKVLKNA KQACQRLGQY RMPFAWAART 540
LFKDTSGNLD KNARFSAIYR QDSNKLSNDD MLKLLADFRK PEKMAKLPVI LGNLDITIDS 600
VSCDFPNYLN SSYIPMRQFE TCSKSPITFE VEEFVPCIPK HTQPYTVYSN HLYVYPKYLK 660
YDSQKSFAKA RNIAICIEFK DSDEEDSQPL KCIYGRPGGP VFTRSALAAV LHHQQNPEFY 720
DEIKIELPAQ LHERHHLLFT FFHVSCDNST KGSTKKKDAV ETQVGFSWLP LLKDGRVLTS 780
EQHIPVSANL PSGYLGYQEL GMGRHYGPEV KWVEGGKPLL KISTHLVSTV YTQDQHLHNF 840
FQYCQKTESG AQASGSELVK YLKSLHAMEG HVMIAFLPTI LNQLFRVLTR ATQEEVAVNV 900
TRVIIHVVAQ CHEEGLESHL RSYVKFAYKA EPYVASEYKT VHEELTKSMT TILKPSADFL 960
TSNKLLKYSW FFFDVLIKSM AQHLIENNKV KLLRNQRFPA SYHHAVETVV NMLMPHITQK 1020
FRDNPEASKN ANHSLAVFIK RCFTFMDRGF VFKQINNYIS CFAPGDPKTL FEYKFEFLRV 1080
VCNHEHYIPL NLPMPFGKGR IQRYQDLQLD YSLTDEFCRN HFLVGLLLRE VGTALQEFRE 1140
VRVIAISMLK NLLIKHSFDD RYNSRSHQAR IATLYLPLFG LLIENVQRIN VRDVSPFPVN 1200
PGSIVKDEAL AVPAGNPLMT PQKGNTLDHS LHKDLLGAIS GIASPYTAST PNINSVRNAD 1260
SRGSLISTDS GNSLPDRNPE KSNSLDKQQQ SGMLGNSVVR CDKLDQSEIK SLLMCFLYVL 1320
KSMSDDALFT YWNKASTAEL MDFFTISEVC LHQFQYMGKR YIARNQEGLG PIGHDRKSQT 1380
LPVSRNRTGM MHARLQQLGS LDNSVTFNHS YGHSEADVVH QSLLEANIAT EVCLTALDTL 1440
SLFTLAFKNQ LLADHGHNPL MKKVFDVYLC FLQKHQSEMA LKNVFTALRS LIYKFPSAFY 1500
EGRADMCASL CYEVLKCCNS KLSSIRTEAS QLLYFLMRNN FDYTGKKSFV RTHLQVIISV 1560
SQLIADVVGI GGTRFQQSLS IINNCANSDR IIKHTSFSSD VKDLTKRIRT VLMATAQMKE 1620
HENDPEMLVD LQYSLAKSYA STPELRKTWL DSMARIHVKN GDLSEAAMCY VHVTALVAEY 1680
LTRKEADLAL QREPPAFPYS HSTCQRKSWG GMFRQGCTAF RVITPNIDEE ASMMEDVGMQ 1740
DVHFNEDVLM ELLEQCADGL WKAERYELIA DIYKLIIPIY EKRRDFERLA HLYDTLHRAY 1800
SKVTEVMHSG RRLLGTYFRV AFFGQGFFED EDGKEYIYKE PKLTPLSEIS QRLLKLYSDK 1860
FGSENVKMIQ DSGKVNPKDL DSKFAYIQVT HVTPFFDEKE LQERRTEFER CHNIRRFMFE 1920
MPFTQTGKRQ GGVEEQCKRR TILTAIHCFP YVKKRIPVMY QHHTDLNPIE VAIDEMSKKV 1980
AELRQLCSSA EVDMIKLQLK LQGSVSVQVN AGPLAYARAF LDDTNTKRYP DNKVKLLKEV 2040
FRQFVEACGQ ALAVNERLIK EDQLEYQEEM KANYREMAKE LSDIMREQIC PLEEKTSVLP 2100
NSLHIFNAIS GTPTSTVVQG LTSSSSVV 2128 
Gene Ontology
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR027007; DHR-1_domain.
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR010703; DOCK_C.
 IPR021816; DOCK_C/D_N.
 IPR026796; DOCK_D.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF06920; Ded_cyto
 PF14429; DOCK-C2
 PF11878; DUF3398
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS51650; DHR_1
 PS51651; DHR_2
 PS50003; PH_DOMAIN 
PRINTS