Tag | Content |
---|
CPLM ID | CPLM-016475 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dedicator of cytokinesis protein 9 |
Protein Synonyms/Alias | Cdc42 guanine nucleotide exchange factor zizimin-1 |
Gene Name | Dock9 |
Gene Synonyms/Alias | D14Wsu89e; Kiaa1058 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
---|
2079 | ANYREMAKELSDIMR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation (By similarity). |
Sequence Annotation | DOMAIN 185 292 PH. DOMAIN 649 827 DHR-1. DOMAIN 1614 2055 DHR-2. MOD_RES 936 936 Phosphoserine. MOD_RES 1244 1244 Phosphoserine (By similarity). MOD_RES 1250 1250 Phosphothreonine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2055 AA |
Protein Sequence | MGCTTSVILF KGIRTVFERN CAYMCKQPGE SNALEYTAYN WSKEDSELSI AFCLAKPKLI 60 EPLDYENVIV QKKTQILNDC LREMLLFPYD DFQTAILRRQ GRYLRSTVPA NAEEEAQSLF 120 VTECIKTYNS DWHLVTYKYE DYSGEFRQLP NKVPKLDKLP VHVYEVDEEA DKDEDAASLG 180 SQKGGITKHG WLYKGNMNSA ISVTMRSFKR RFFHLIQLGD GSYNLNFYKD EKISKEPKGS 240 IFLDSCMGVI QNNRVRRFAF ELKMQDKSSY LLAADSEAEM EEWVTVLNKI LQLNFEAAMQ 300 EKRNGDPHED DEQSKLEGSG SGLDSYLPEL AKSTREAEIK LKSESRVKLF YLDPDTQKLD 360 FSSAEPEVKP FEEKFGKRIL VKCNDLSFNL QCCVAENEEG PTTNVEPFFV TLSLFDIKYN 420 RKISADFHVD LNHFSVRQML APTSPALMNG GQSPPAFQDA LHTAMQYPKQ GIFSVTCPHP 480 DIFLVARIEK VLQGSITHCA EPYMRSSDSS KVAQKVLKNA KQACQRLGQY RMPFAWAART 540 LFKDTSGNLD KNARFSAIYR QDSNKLSNDD MLKLLADFRK PEKMAKLPVI LGNLDITIDS 600 VSCDFPNYLN SSYIPMRQFE TCSKSPITFE VEEFVPCIPK HTQPYTVYSN HLYVYPKYLK 660 YDSQKSFAKA RNIAICIEFK DSDEEDSQPL KCIYGRPGGP VFTRSALAAV LHHQQNPEFY 720 DEIKIELPAQ LHERHHLLFT FFHVSCDNST KGSTKKKDAV ETQVGFSWLP LLKDGRVLTS 780 EQHIPVSANL PSGYLGYQEL GMGRHYGPEV KWVEGGKPLL KISTHLVSTV YTQDQHLHNF 840 FQYCQKTESG AQASGSELVK YLKSLHAMEG HVMIAFLPTI LNQLFRVLTR ATQEEVAVNV 900 TRVIIHVVAQ CHEEGLESHL RSYVKFAYKA EPYVASEYKT VHEELTKSMT TILKPSADFL 960 TSNKLLKYSW FFFDVLIKSM AQHLIENNKV KLLRNQRFPA SYHHAVETVV NMLMPHITQK 1020 FRDNPEASKN ANHSLAVFIK RCFTFMDRGF VFKQINNYIS CFAPGDPKTL FEYKFEFLRV 1080 VCNHEHYIPL NLPMPFGKGR IQRYQDLQLD YSLTDEFCRN HFLVGLLLRE VGTALQEFRE 1140 VRVIAISMLK NLLIKHSFDD RYNSRSHQAR IATLYLPLFG LLIENVQRIN VRDVSPFPVN 1200 PGSIVKDEAL AVPAGNPLMT PQKGNTLDHS LHKDLLGAIS GIASPYTAST PNINSVRNAD 1260 SRGSLISTDS GNSLPDRNPE KSNSLDKQQQ SGMLGNSVVR CDKLDQSEIK SLLMCFLYVL 1320 KSMSDDALFT YWNKASTAEL MDFFTISEVC LHQFQYMGKR YIARNQEGLG PIGHDRKSQT 1380 LPVSRNRTGM MHARLQQLGS LDNSVTFNHS YGHSEADVVH QSLLEANIAT EVCLTALDTL 1440 SLFTLAFKNQ LLADHGHNPL MKKVFDVYLC FLQKHQSEMA LKNVFTALRS LIYKFPSAFY 1500 EGRADMCASL CYEVLKCCNS KLSSIRTEAS QLLYFLMRNN FDYTGKKSFV RTHLQVIISV 1560 SQLIADVVGI GGTRFQQSLS IINNCANSDR IIKHTSFSSD VKDLTKRIRT VLMATAQMKE 1620 HENDPEMLVD LQYSLAKSYA STPELRKTWL DSMARIHVKN GDLSEAAMCY VHVTALVAEY 1680 LTRKEADLAL QREPPAFPYS HSTCQRKSWG GMFRQGCTAF RVITPNIDEE ASMMEDVGMQ 1740 DVHFNEDVLM ELLEQCADGL WKAERYELIA DIYKLIIPIY EKRRDFERLA HLYDTLHRAY 1800 SKVTEVMHSG RRLLGTYFRV AFFGQGFFED EDGKEYIYKE PKLTPLSEIS QRLLKLYSDK 1860 FGSENVKMIQ DSGKVNPKDL DSKFAYIQVT HVTPFFDEKE LQERRTEFER CHNIRRFMFE 1920 MPFTQTGKRQ GGVEEQCKRR TILTAIHCFP YVKKRIPVMY QHHTDLNPIE VAIDEMSKKV 1980 AELRQLCSSA EVDMIKLQLK LQGSVSVQVN AGPLAYARAF LDDTNTKRYP DNKVKLLKEV 2040 FRQFVEACGQ ALAVNERLIK EDQLEYQEEM KANYREMAKE LSDIMREQIC PLEEKTSVLP 2100 NSLHIFNAIS GTPTSTVVQG LTSSSSVV 2128 |
Gene Ontology | GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:MGI. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |