| Tag | Content |
|---|
| CPLM ID | CPLM-000822 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Choline/ethanolamine kinase |
Protein Synonyms/Alias | Choline kinase beta; CK; CKB; Ethanolamine kinase; EK; choline/ethanolamine kinase beta; CKEKB |
Gene Name | Chkb |
Gene Synonyms/Alias | Chetk; Chkl |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 170 | LSGAIATKMARFHGM | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis (By similarity). |
Sequence Annotation | NP_BIND 75 81 ATP (By similarity).
NP_BIND 146 152 ATP (By similarity).
REGION 77 79 Substrate binding (By similarity).
BINDING 104 104 ATP (By similarity).
BINDING 244 244 ATP (By similarity).
BINDING 264 264 ATP (By similarity).
MOD_RES 2 2 N-acetylalanine (By similarity). |
Keyword | Acetylation; ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Lipid biosynthesis; Lipid metabolism; Nucleotide-binding; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 394 AA |
Protein Sequence | MAADGTGVVG GGAVGGPLSK DGLLDAKCPE PIPNRRRSSS LSRDAQRRAY QWCREYLGGA 60
WRRARPEELS VCPVSGGLSN LLFRCSLPNH VPSMGGEPRE VLLRLYGAIL QGVDSLVLES 120
VMFAILAERS LGPQLYGVFP EGRLEQYLPS RPLKTQELRD PVLSGAIATK MARFHGMEMP 180
FTKEPRWLFG TMERYLKQIQ DLPSTSLPQM NLVEMYSLKD EMNHLRTLLD ATPSPVVFCH 240
NDIQEGNILL LSEPDSDDNL MLVDFEYSSY NYRGFDIGNH FCEWVYDYTY EEWPFYKARP 300
ADYPTREQQL LFIRHYLAEV QKGEVLSEEE QKKQEEDLLI EISRYALASH FFWGLWSTLQ 360
ASMSTIEFGY LEYAQSRFQF YFQQKGQLTS FLSP 394 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004103; F:choline kinase activity; ISS:UniProtKB. GO:0004305; F:ethanolamine kinase activity; IEA:EC. GO:0007517; P:muscle organ development; IEA:Compara. GO:0006646; P:phosphatidylethanolamine biosynthetic process; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |