CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013605
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Major urinary protein 20 
Protein Synonyms/Alias
 Darcin; Major urinary protein 24 
Gene Name
 Mup20 
Gene Synonyms/Alias
 Mup24 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
127IMIHLINKKDGETFQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Male pheromone which stimulates female sexual attraction to male urinary scent and promotes a strong learned attraction to the airborne urinary odor of an individual male. Promotes male agressive behavior. Binds most of the male pheromone, 2-sec-butyl- 4,5-dihydrothiazole, in urine. 
Sequence Annotation
 DISULFID 83 176 By similarity.  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Pheromone; Pheromone-binding; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 181 AA 
Protein Sequence
MKLLVLLLCL GLTLVCVHAE EASSMERNFN VEKINGEWYT IMLATDKREK IEEHGSMRVF 60
VEYIHVLENS LALKFHIIIN EECSEIFLVA DKTEKAGEYS VTYDGSNTFT ILKTDYDNYI 120
MIHLINKKDG ETFQLMELYG REPDLSSDIK EKFAQLSEEH GIVRENIIDL TNANRCLEAR 180
E 181 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005615; C:extracellular space; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005009; F:insulin-activated receptor activity; ISS:UniProtKB.
 GO:0000772; F:mating pheromone activity; IDA:MGI.
 GO:0005550; F:pheromone binding; IDA:MGI.
 GO:0036094; F:small molecule binding; IEA:InterPro.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0009060; P:aerobic respiration; ISS:UniProtKB.
 GO:0071396; P:cellular response to lipid; ISS:UniProtKB.
 GO:0006112; P:energy reserve metabolic process; ISS:UniProtKB.
 GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
 GO:0031649; P:heat generation; ISS:UniProtKB.
 GO:0045475; P:locomotor rhythm; ISS:UniProtKB.
 GO:0070584; P:mitochondrion morphogenesis; ISS:UniProtKB.
 GO:0045721; P:negative regulation of gluconeogenesis; ISS:UniProtKB.
 GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; ISS:UniProtKB.
 GO:0051055; P:negative regulation of lipid biosynthetic process; ISS:UniProtKB.
 GO:0010888; P:negative regulation of lipid storage; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0008355; P:olfactory learning; IDA:MGI.
 GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
 GO:0010907; P:positive regulation of glucose metabolic process; ISS:UniProtKB.
 GO:0045834; P:positive regulation of lipid metabolic process; ISS:UniProtKB.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; ISS:UniProtKB. 
Interpro
 IPR012674; Calycin.
 IPR011038; Calycin-like.
 IPR002345; Lipocalin.
 IPR022272; Lipocalin_CS.
 IPR000566; Lipocln_cytosolic_FA-bd_dom.
 IPR002971; Maj_urinary. 
Pfam
 PF00061; Lipocalin 
SMART
  
PROSITE
 PS00213; LIPOCALIN 
PRINTS
 PR00179; LIPOCALIN.
 PR01221; MAJORURINARY.