CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018177
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prostaglandin reductase 2 
Protein Synonyms/Alias
 PRG-2; 15-oxoprostaglandin 13-reductase; Zinc-binding alcohol dehydrogenase domain-containing protein 1 
Gene Name
 Ptgr2 
Gene Synonyms/Alias
 Zadh1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
14VLNSRPGKNGNPVAEubiquitination[1]
293RFTVLNYKDKFEPGIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. 
Sequence Annotation
 NP_BIND 165 168 NADP.
 NP_BIND 253 259 NADP.
 NP_BIND 287 289 NADP.
 REGION 99 100 Substrate binding (By similarity).
 REGION 288 290 Substrate binding (By similarity).
 BINDING 192 192 NADP.
 BINDING 208 208 NADP.
 BINDING 231 231 NADP.
 BINDING 337 337 NADP.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 351 AA 
Protein Sequence
MIIQRVVLNS RPGKNGNPVA ENFRVEEFSL PDALNEGQVQ VRTLYLSVDP YMRCKMNEDT 60
GTDYLAPWQL AQVADGGGIG VVEESKHQKL TKGDFVTSFY WPWQTKAILD GNGLEKVDPQ 120
LVDGHLSYFL GAIGMPGLTS LIGVQEKGHI SAGSNQTMVV SGAAGACGSL AGQIGHLLGC 180
SRVVGICGTQ EKCLFLTSEL GFDAAVNYKT GNVAEQLREA CPGGVDVYFD NVGGDISNAV 240
ISQMNENSHI ILCGQISQYS NDVPYPPPLP PAVEAIRKER NITRERFTVL NYKDKFEPGI 300
LQLSQWFKEG KLKVKETMAK GLENMGVAFQ SMMTGGNVGK QIVCISEDSS L 351 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0036132; F:13-prostaglandin reductase activity; IEA:EC.
 GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; ISS:UniProtKB.
 GO:0006693; P:prostaglandin metabolic process; ISS:UniProtKB. 
Interpro
 IPR013149; ADH_C.
 IPR002085; ADH_SF_Zn-type.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00107; ADH_zinc_N 
SMART
  
PROSITE
  
PRINTS