UniProt Accession

 Q8C243_MOUSE; Q8C243 

Genbank Protein ID

 AK089294 

Genbank Nucleotide ID

 BAC40831.1 

Protein Name

 Putative uncharacterized protein 

Protein Synonyms/Alias

  

Gene Name

 Ctsd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
62	YSMQSSPKTTEPVSE	ubiquitination	[1]
174	ARGIKVEKQIFGEAT	ubiquitination	[1]
182	QIFGEATKQPGIVFV	ubiquitination	[1]
339	SLPTVYLKLGGKNYE	ubiquitination	[1]
351	NYELHPDKYILKVSQ	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

  

Sequence Annotation

  

Keyword

 Aspartyl protease; Disulfide bond; Hydrolase; Protease. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 445 AA 

Protein Sequence

Gene Ontology

 GO:0005764; C:lysosome; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004190; F:aspartic-type endopeptidase activity; IDA:MGI.
 GO:0000045; P:autophagic vacuole assembly; IMP:MGI.
 GO:0006508; P:proteolysis; IC:MGI. 

Interpro

 IPR001461; Peptidase_A1.
 IPR021109; Peptidase_aspartic.
 IPR001969; Peptidase_aspartic_AS.
 IPR012848; Propep_A1. 

Pfam

 PF07966; A1_Propeptide
 PF00026; Asp 

SMART

  

PROSITE

 PS00141; ASP_PROTEASE 

PRINTS

 PR00792; PEPSIN.