| Tag | Content |
|---|
| CPLM ID | CPLM-014722 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rap1 GTPase-activating protein 2 |
Protein Synonyms/Alias | Rap1GAP2; GTPase-activating Rap/Ran-GAP domain-like protein 4 |
Gene Name | RAP1GAP2 |
Gene Synonyms/Alias | GARNL4; KIAA1039; RAP1GA2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 201 | IPLAGLSKLPSVPQI | ubiquitination | [1] | | 409 | PSPPVFQKGPEFREF | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. |
Sequence Annotation | DOMAIN 248 464 Rap-GAP.
MOD_RES 7 7 Phosphoserine; by PKG/PRKG1; in vitro.
MOD_RES 45 45 Phosphoserine.
MOD_RES 49 49 Phosphothreonine.
MOD_RES 544 544 Phosphoserine.
MOD_RES 558 558 Phosphoserine.
MOD_RES 564 564 Phosphoserine.
MOD_RES 613 613 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; GTPase activation; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 730 AA |
Protein Sequence | MFGRKRSVSF GGFGWIDKTM LASLKVKKQE LANSSDATLP DRPLSPPLTA PPTMKSSEFF 60
EMLEKMQDDY IPYPSIDEVV EKGGPYPQVI LPQFGGYWIE DPENVGTPTS LGSSICEEEE 120
EDNLSPNTFG YKLECKGEAR AYRRHFLGKD HLNFYCTGSS LGNLILSVKC EEAEGIEYLR 180
VILRSKLKTV HERIPLAGLS KLPSVPQIAK AFCDDAVGLR FNPVLYPKAS QMIVSYDEHE 240
VNNTFKFGVI YQKARQTLEE ELFGNNEESP AFKEFLDLLG DTITLQDFKG FRGGLDVTHG 300
QTGVESVYTT FRDREIMFHV STKLPFTDGD AQQLQRKRHI GNDIVAIIFQ EENTPFVPDM 360
IASNFLHAYI VVQVETPGTE TPSYKVSVTA REDVPTFGPP LPSPPVFQKG PEFREFLLTK 420
LTNAENACCK SDKFAKLEDR TRAALLDNLH DELHAHTQAM LGLGPEEDKF ENGGHGGFLE 480
SFKRAIRVRS HSMETMVGGQ KKSHSGGIPG SLSGGISHNS MEVTKTTFSP PVVAATVKNQ 540
SRSPIKRRSG LFPRLHTGSE GQGDSRARCD STSSTPKTPD GGHSSQEIKS ETSSNPSSPE 600
ICPNKEKPFM KLKENGRAIS RSSSSTSSVS STAGEGEAME EGDSGGSQPS TTSPFKQEVF 660
VYSPSPSSES PSLGAAATPI IMSRSPTDAK SRNSPRSNLK FRFDKLSHAS SGAGH 715 |
Gene Ontology | GO:0005813; C:centrosome; IDA:UniProtKB. GO:0005829; C:cytosol; TAS:Reactome. GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |