UniProt Accession

 FKBP2_MOUSE; P45878 

Genbank Protein ID

 M77831; BC031824; BC053692 

Genbank Nucleotide ID

 AAA37631.1; AAH31824.1; AAH53692.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase FKBP2 

Protein Synonyms/Alias

 PPIase FKBP2; 13 kDa FK506-binding protein; 13 kDa FKBP; FKBP-13; FK506-binding protein 2; FKBP-2; Immunophilin FKBP13; Rotamase 

Gene Name

 Fkbp2 

Gene Synonyms/Alias

 Fkbp13 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
99	LGMCEGEKRKLVIPS	acetylation	[1]
101	MCEGEKRKLVIPSEL	acetylation	[1, 2]
101	MCEGEKRKLVIPSEL	succinylation	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 

Sequence Annotation

 DOMAIN 47 135 PPIase FKBP-type.
 MOTIF 137 140 Prevents secretion from ER (Potential).  

Keyword

 Complete proteome; Endoplasmic reticulum; Isomerase; Membrane; Reference proteome; Rotamase; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 140 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IBA:RefGenome.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW. 

Interpro

 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 

Pfam

 PF00254; FKBP_C 

SMART

  

PROSITE

 PS50059; FKBP_PPIASE 

PRINTS