UniProt Accession

 SGF29_MOUSE; Q9DA08; Q8R0I6 

Genbank Protein ID

 AK006287; AK139102; AK169898; BC026784 

Genbank Nucleotide ID

 BAB24506.1; BAE23890.1; BAE41445.1; AAH26784.1 

Protein Name

 SAGA-associated factor 29 homolog 

Protein Synonyms/Alias

 Coiled-coil domain-containing protein 101 

Gene Name

 Ccdc101 

Gene Synonyms/Alias

 Sgf29 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
99	EERRIAAKIAGLYND	acetylation	[1]
288	QRYVVACKEPKKK**	acetylation	[1, 2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation (By similarity). 

Sequence Annotation

 DOMAIN 152 293 SGF29 C-terminal.
 REGION 194 196 Histone H3K4me3 N-terminus binding (By
 REGION 240 243 Histone H3K4me3 N-terminus binding (By
 REGION 264 266 Histone H3K4me3 binding (By similarity).
 BINDING 238 238 Histone H3K4me3 (By similarity).
 BINDING 245 245 Histone H3K4me3 (By similarity).
 MOD_RES 288 288 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Chromatin regulator; Coiled coil; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 293 AA 

Protein Sequence

Gene Ontology

 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:MGI.
 GO:0070461; C:SAGA-type complex; ISS:UniProtKB.
 GO:0035064; F:methylated histone residue binding; ISS:UniProtKB.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR010750; SGF29_tudor-like_dom. 

Pfam

 PF07039; DUF1325 

SMART

  

PROSITE

 PS51518; SGF29_C 

PRINTS