CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043530
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Leucine-rich repeat-containing protein 57 
Protein Synonyms/Alias
  
Gene Name
 LRRC57 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15AHVETAQKTGVFQLKubiquitination[1]
22KTGVFQLKDRGLTEFubiquitination[1]
35EFPADLQKLTSNLRTubiquitination[1, 2]
49TIDLSNNKIESLPPLubiquitination[1]
60LPPLLIGKFTLLKSLubiquitination[1]
86DEICNLKKLETLSLNubiquitination[1]
140LDVMDLSKNQIRSIPubiquitination[2, 3, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Leucine-rich repeat; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 148 AA 
Protein Sequence
MGNSALRAHV ETAQKTGVFQ LKDRGLTEFP ADLQKLTSNL RTIDLSNNKI ESLPPLLIGK 60
FTLLKSLSLN NNKLTVLPDE ICNLKKLETL SLNNNHLREL PSTFGQLSAL KTLSLSGNQL 120
GALPPQLCSL RHLDVMDLSK NQIRSIPD 148 
Gene Ontology
  
Interpro
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003591; Leu-rich_rpt_typical-subtyp. 
Pfam
 PF12799; LRR_4 
SMART
 SM00369; LRR_TYP 
PROSITE
 PS51450; LRR 
PRINTS