UniProt Accession

 DCP1A_HUMAN; Q9NPI6 

Genbank Protein ID

 AY146651; AJ275986; AK001969; AC097015; AC112218; BC007439 

Genbank Nucleotide ID

 AAN62763.1; CAB77023.1; BAA92008.1; AAH07439.1 

Protein Name

 mRNA-decapping enzyme 1A 

Protein Synonyms/Alias

 Smad4-interacting transcriptional co-activator; Transcription factor SMIF 

Gene Name

 DCP1A 

Gene Synonyms/Alias

 SMIF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	PKANQWEKTDIEGTL	ubiquitination	[1, 2]
120	NDCHRIAKLMADVVE	ubiquitination	[2]
140	SQQAARDKQSPSQAN	ubiquitination	[2]
397	PSVDLLQKLRLTPQH	ubiquitination	[2, 3]
537	GTPESQRKPSIILSK	ubiquitination	[2]

Reference

 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. 

Sequence Annotation

 MOD_RES 142 142 Phosphoserine.
 MOD_RES 180 180 Phosphoserine.
 MOD_RES 315 315 Phosphoserine.
 MOD_RES 319 319 Phosphoserine.
 MOD_RES 334 334 Phosphoserine.
 MOD_RES 353 353 Phosphoserine.
 MOD_RES 401 401 Phosphothreonine.
 MOD_RES 422 422 Phosphoserine.
 MOD_RES 522 522 Phosphoserine.
 MOD_RES 523 523 Phosphoserine.
 MOD_RES 525 525 Phosphoserine.
 MOD_RES 531 531 Phosphothreonine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Nonsense-mediated mRNA decay; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 582 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; ISS:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; TAS:Reactome.
 GO:0010467; P:gene expression; TAS:Reactome.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW. 

Interpro

 IPR010334; DCP1.
 IPR011993; PH_like_dom. 

Pfam

 PF06058; DCP1 

SMART

  

PROSITE

  

PRINTS