CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006778
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2-dehydro-3-deoxygluconokinase 
Protein Synonyms/Alias
 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase 
Gene Name
 kdgK 
Gene Synonyms/Alias
 yhjI; b3526; JW5668 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
148LSPTSREKLLSLLREacetylation[1]
162ECRANGGKVIFDNNYacetylation[1]
255AVKLPKEKVIDTTAAacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). 
Sequence Annotation
 NP_BIND 168 170 ATP (By similarity).
 NP_BIND 228 234 ATP (By similarity).
 NP_BIND 261 264 ATP (By similarity).
 REGION 102 104 Substrate binding (By similarity).
 ACT_SITE 264 264 Proton acceptor (By similarity).
 BINDING 88 88 Substrate (By similarity).
 BINDING 170 170 Substrate (By similarity).
 BINDING 197 197 ATP (By similarity).
 BINDING 264 264 Substrate (By similarity).  
Keyword
 ATP-binding; Carbohydrate metabolism; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 309 AA 
Protein Sequence
MSKKIAVIGE CMIELSEKGA DVKRGFGGDT LNTSVYIARQ VDPAALTVHY VTALGTDSFS 60
QQMLDAWHGE NVDTSLTQRM ENRLPGLYYI ETDSTGERTF YYWRNEAAAK FWLESEQSAA 120
ICEELANFDY LYLSGISLAI LSPTSREKLL SLLRECRANG GKVIFDNNYR PRLWASKEET 180
QQVYQQMLEC TDIAFLTLDD EDALWGQQPV EDVIARTHNA GVKEVVVKRG ADSCLVSIAG 240
EGLVDVPAVK LPKEKVIDTT AAGDSFSAGY LAVRLTGGSA EDAAKRGHLT ASTVIQYRGA 300
IIPREAMPA 309 
Gene Ontology
 GO:0008673; F:2-dehydro-3-deoxygluconokinase activity; IDA:EcoCyc.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0019698; P:D-galacturonate catabolic process; IMP:EcoCyc.
 GO:0042840; P:D-glucuronate catabolic process; IMP:EcoCyc.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. 
Interpro
 IPR002173; Carboh/pur_kinase_PfkB_CS.
 IPR011611; PfkB_dom. 
Pfam
 PF00294; PfkB 
SMART
  
PROSITE
 PS00583; PFKB_KINASES_1
 PS00584; PFKB_KINASES_2 
PRINTS