CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038188
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transporter 
Protein Synonyms/Alias
  
Gene Name
 Slc6a12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
545NCSSSPAKQELIAWEubiquitination[1]
553QELIAWEKETHL***ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MDRKVAVHED GYPVVSWVPE EGEMMDQKGK DQVKDRGQWT NKMEFVLSVA GEIIGLGNVW 60
RFPYLCYKNG GGAFFIPYFI FFFSCGIPVF FLEVALGQYS SQGSVTAWRK ICPLLQGIGM 120
ASVVIESYLN IYYIIILAWA LFYLFSSFTW ELPWTTCTNS WNTEHCVDFL NHSSARGVSS 180
SENFTSPVME FWERRVLGIT SGIHDLGSLR WELALCLLLA WIICYFCIWK GVKSTGKVVY 240
FTATFPYLML IILLIRGVTL PGAYQGIVFY LKPDLLRLKD PQVWMDAGTQ IFFSFAICQG 300
CLTALGSYNK YHNNCYRDSI ALCFLNSATS FVAGFVVFSI LGFMSQEQGI PISEVAESGP 360
GLAFIAFPKA VTMMPLSQLW SCLFFIMLLF LGLDSQFVCM ECLVTASMDM FPQQLRKSGR 420
RELLILAISV LCYLMGLLLV TEGGMYIFQL FDYYASSGIC LLFLSLFEVI CIGWVYGADR 480
FYDNVEDMIG YRPWPLVKIS WLFLTPGLCL RLRRLITPDP SLPQPGRRPP QDGSSAQNCS 540
SSPAKQELIA WEKETHL 557 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005332; F:gamma-aminobutyric acid:sodium symporter activity; IEA:InterPro.
 GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro. 
Interpro
 IPR000175; Na/ntran_symport.
 IPR002983; Na/ntran_symport_betaine. 
Pfam
 PF00209; SNF 
SMART
  
PROSITE
 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 
PRINTS
 PR01198; BETTRANSPORT.
 PR00176; NANEUSMPORT.