CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030555
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FAS-associated factor 1 
Protein Synonyms/Alias
 cDNA FLJ37524 fis, clone BRCAN2007119, highly similar to FAS-associated factor 1 
Gene Name
 FAF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
27SSTIQEVKRNVYDLTubiquitination[1, 2, 3, 4, 5, 6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 464 AA 
Protein Sequence
MLIITHREVQ REYNLNFSGS STIQEVKRNV YDLTSIPVRH QLWEGWPTSA TDDSMCLAES 60
GLSYPCHRLT VGRRSSPAQT REQSEEQITD VHMVSDSDGD DFEDATEFGV DDGEVFGMAS 120
SALRKSPMMP ENAENEGDAL LQFTAEFSSR YGDCHPVFFI GSLEAAFQEA FYVKARDRKL 180
LAIYLHHDES VLTNVFCSQM LCAESIVSYL SQNFITWAWD LTKDSNRARF LTMCNRHFGS 240
VVAQTIRTQK TDQFPLFLII MGKRSSNEVL NVIQGNTTVD ELMMRLMAAM EIFTAQQQED 300
IKDEDEREAR ENVKREQDEA YRLSLEADRA KREAHEREMA EQFRLEQIRK EQEEEREAIR 360
LSLEQALPPE PKEENAEPVS KLRIRTPSGE FLERRFLASN KLQIVFDFVA SKGFPWDEYK 420
LLSTFPRRDI PGLSRMGKHA CSRSLYIHFM FFILILKTWI ISCF 464 
Gene Ontology
  
Interpro
 IPR006577; UAS.
 IPR001012; UBX. 
Pfam
 PF00789; UBX 
SMART
 SM00594; UAS
 SM00166; UBX 
PROSITE
 PS50033; UBX 
PRINTS