CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041302
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Excision repair cross-complementing rodent repair deficiency, complementation group 3 (Xeroderma pigmentosum group B complementing), isoform CRA_b 
Protein Synonyms/Alias
 TFIIH basal transcription factor complex helicase XPB subunit 
Gene Name
 ERCC3 
Gene Synonyms/Alias
 hCG_42607 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
158TSKSAISKTAESSGGubiquitination[1, 2, 3]
513EYAIRLNKPYIYGPTubiquitination[2]
533MQILQNFKHNPKINTubiquitination[2]
537QNFKHNPKINTIFISubiquitination[4]
642EDLAFSTKEEQQQLLubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 718 AA 
Protein Sequence
MPLKDDHTSR PLWVAPDGHI FLEAFSPVYK YAQDFLVAIA EPVCRPTHVH EYKLTAYSLY 60
AAVSVGLQTS DITEYLRKLS KTGVPDGIMQ FIKLCTVSYG KVKLVLKHNR YFVESCHPDV 120
IQHLLQDPVI RECRLRNSEG EATELITETF TSKSAISKTA ESSGGPSTSR VTDPQGKSDI 180
PMDLFDFYEQ MDKDEEEEEE TQTVSFEVKQ EMIEELQKRC IHLEYPLLAE YDFRNDSVNP 240
DINIDLKPTA VLRPYQEKSL RKMFGNGRAR SGVIVLPCGA GKSLVGVTAA CTVRKRCLVL 300
GNSAVSVEQW KAQFKMWSTI DDSQICRFTS DAKDKPIGCS VAISTYSMLG HTTKRSWEAE 360
RVMEWLKTQE WGLMILDEVH TIPAKMFRRV LTIVQAHCKL GLTATLVRED DKIVDLNFLI 420
GPKLYEANWM ELQNNGYIAK VQCAEVWCPM SPEFYREYVA IKTKKRILLY TMNPNKFRAC 480
QFLIKFHERR NDKIIVFADN VFALKEYAIR LNKPYIYGPT SQGERMQILQ NFKHNPKINT 540
IFISKVGDTS FDLPEANVLI QISSHGGSRR QEAQRLGRVL RAKKGMVAEE YNAFFYSLVS 600
QDTQEMAYST KRQRFLVDQG YSFKVITKLA GMEEEDLAFS TKEEQQQLLQ KVLAATDLDA 660
EEEVVAGEFG SRSSQASRRF GTMSSMSGAD DTVYMEYHSS RSKAPSKHVH PLFKRFRK 718 
Gene Ontology
 GO:0000441; C:SSL2-core TFIIH complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0004003; F:ATP-dependent DNA helicase activity; IEA:Compara.
 GO:0032564; F:dATP binding; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:Compara.
 GO:0042277; F:peptide binding; IEA:Compara.
 GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
 GO:0006468; P:protein phosphorylation; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0009650; P:UV protection; IEA:Compara. 
Interpro
 IPR006935; Helicase/UvrB_dom.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR001161; Helicase_Ercc3.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00271; Helicase_C
 PF04851; ResIII 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS
 PR00851; XRODRMPGMNTB.