UniProt Accession

 BCAT2_HUMAN; O15382; B2RB87; O00269; Q96KG1; Q9BTB6; Q9BUU6 

Genbank Protein ID

 U68418; AF268047; AF268048; AK314548; CH471177; BC001900; BC004243; U62739 

Genbank Nucleotide ID

 AAB67672.1; AAK38368.1; AAK38369.1; BAG37134.1; EAW52403.1; AAH01900.1; AAH04243.2; AAB53087.1 

Protein Name

 Branched-chain-amino-acid aminotransferase, mitochondrial 

Protein Synonyms/Alias

 BCAT(m); Placental protein 18; PP18 

Gene Name

 BCAT2 

Gene Synonyms/Alias

 BCATM; BCT2; ECA40 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
14	GQLFEGMKAFKGKDQ	ubiquitination	[1]
137	VGGVGNYKLGGNYGP	ubiquitination	[2]
154	LVQQEALKRGCEQVL	ubiquitination	[2]
285	LRFQKELKEIQYGIR	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. 

Sequence Annotation

 BINDING 168 168 Substrate.
 MOD_RES 229 229 N6-(pyridoxal phosphate)lysine.
 MOD_RES 321 321 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Amino-acid biosynthesis; Aminotransferase; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Mitochondrion; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 392 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0004084; F:branched-chain-amino-acid transaminase activity; EXP:Reactome.
 GO:0052656; F:L-isoleucine transaminase activity; IEA:EC.
 GO:0052654; F:L-leucine transaminase activity; IEA:EC.
 GO:0052655; F:L-valine transaminase activity; IEA:EC.
 GO:0009082; P:branched-chain amino acid biosynthetic process; TAS:ProtInc.
 GO:0009083; P:branched-chain amino acid catabolic process; TAS:Reactome.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0006550; P:isoleucine catabolic process; IEA:Compara.
 GO:0006551; P:leucine metabolic process; IEA:Compara.
 GO:0010817; P:regulation of hormone levels; IEA:Compara.
 GO:0006573; P:valine metabolic process; IEA:Compara. 

Interpro

 IPR001544; Aminotrans_IV.
 IPR018300; Aminotrans_IV_CS.
 IPR005786; B_amino_transII. 

Pfam

 PF01063; Aminotran_4 

SMART

  

PROSITE

 PS00770; AA_TRANSFER_CLASS_4 

PRINTS