UniProt Accession

 PMF1_HUMAN; Q6P1K2; A8K0C5; Q5TCJ8; Q5TCJ9; Q5TCK0; Q5TCK1; Q5TCK3; Q69YZ9; Q6PHR4; Q6ZVE6; Q86VJ6; Q8N4T6; Q9UBQ3 

Genbank Protein ID

 AF141309; AF141308; AF141310; AK124646; AK289490; AK290260; AL135927; AL135927; AL135927; AL135927; AL135927; CH471121; CH471121; BC033656; BC050735; BC056417; BC065031; AL080101 

Genbank Nucleotide ID

 AAD50080.1; AAD50080.1; AAD50081.1; BAC85916.1; BAF82179.1; BAF82949.1; CAI15535.1; CAI15536.1; CAI15538.1; CAI15539.1; CAI15540.2; EAW52989.1; EAW52990.1; AAH50735.1; AAH56417.1; AAH65031.1; CAH10730.1 

Protein Name

 Polyamine-modulated factor 1 

Protein Synonyms/Alias

 PMF-1 

Gene Name

 PMF1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	GTTISRVKLLDTMVD	ubiquitination	[1]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Activator; Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Coiled coil; Complete proteome; Kinetochore; Mitosis; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000444; C:MIS12/MIND type complex; IDA:UniProtKB.
 GO:0005667; C:transcription factor complex; TAS:ProtInc.
 GO:0003713; F:transcription coactivator activity; IMP:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007059; P:chromosome segregation; IMP:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR007128; Nnf1. 

Pfam

 PF03980; Nnf1 

SMART

  

PROSITE

  

PRINTS