CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003914
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fibroblast growth factor receptor 1 
Protein Synonyms/Alias
 FGFR-1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD331 
Gene Name
 FGFR1 
Gene Synonyms/Alias
 BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
164SPEKMEKKLHAVPAAacetylation[1]
172LHAVPAAKTVKFKCPacetylation[1]
482RDRLVLGKPLGEGCFubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. 
Sequence Annotation
 DOMAIN 25 119 Ig-like C2-type 1.
 DOMAIN 158 246 Ig-like C2-type 2.
 DOMAIN 255 357 Ig-like C2-type 3.
 DOMAIN 478 767 Protein kinase.
 NP_BIND 484 490 ATP.
 NP_BIND 562 564 ATP.
 REGION 160 177 Heparin-binding.
 ACT_SITE 623 623 Proton acceptor.
 BINDING 514 514 ATP.
 BINDING 568 568 ATP.
 BINDING 627 627 ATP.
 BINDING 641 641 ATP.
 MOD_RES 463 463 Phosphotyrosine; by autocatalysis.
 MOD_RES 583 583 Phosphotyrosine; by autocatalysis.
 MOD_RES 585 585 Phosphotyrosine; by autocatalysis.
 MOD_RES 653 653 Phosphotyrosine; by autocatalysis.
 MOD_RES 654 654 Phosphotyrosine; by autocatalysis.
 MOD_RES 730 730 Phosphotyrosine; by autocatalysis.
 MOD_RES 766 766 Phosphotyrosine; by autocatalysis.
 CARBOHYD 77 77 N-linked (GlcNAc...) (Potential).
 CARBOHYD 117 117 N-linked (GlcNAc...) (Potential).
 CARBOHYD 227 227 N-linked (GlcNAc...) (Potential).
 CARBOHYD 240 240 N-linked (GlcNAc...) (Potential).
 CARBOHYD 264 264 N-linked (GlcNAc...) (Potential).
 CARBOHYD 296 296 N-linked (GlcNAc...).
 CARBOHYD 317 317 N-linked (GlcNAc...) (Potential).
 CARBOHYD 330 330 N-linked (GlcNAc...) (Potential).
 DISULFID 55 101 By similarity.
 DISULFID 178 230
 DISULFID 277 341  
Keyword
 3D-structure; Alternative splicing; ATP-binding; Cell membrane; Chromosomal rearrangement; Complete proteome; Craniosynostosis; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Disease mutation; Disulfide bond; Dwarfism; Glycoprotein; Heparin-binding; Hypogonadotropic hypogonadism; Immunoglobulin domain; Kallmann syndrome; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transcription; Transcription regulation; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 822 AA 
Protein Sequence
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD 60
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD 120
ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS 180
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN 240
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI 300
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE 360
ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS 420
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL 480
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK 540
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL 600
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG 660
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD 720
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF 780
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR 822 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017134; F:fibroblast growth factor binding; IDA:UniProtKB.
 GO:0005007; F:fibroblast growth factor-activated receptor activity; IDA:UniProtKB.
 GO:0008201; F:heparin binding; IDA:UniProtKB.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0060117; P:auditory receptor cell development; IEA:Compara.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0060445; P:branching involved in salivary gland morphogenesis; IEA:Compara.
 GO:0048469; P:cell maturation; IEA:Compara.
 GO:0002062; P:chondrocyte differentiation; IEA:Compara.
 GO:0043009; P:chordate embryonic development; TAS:UniProtKB.
 GO:0030326; P:embryonic limb morphogenesis; IEA:Compara.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0035607; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0042472; P:inner ear morphogenesis; IEA:Compara.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0060484; P:lung-associated mesenchyme development; IEA:Compara.
 GO:0000165; P:MAPK cascade; TAS:ProtInc.
 GO:0048762; P:mesenchymal cell differentiation; IEA:Compara.
 GO:0030901; P:midbrain development; IEA:Compara.
 GO:0042474; P:middle ear morphogenesis; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0001764; P:neuron migration; TAS:UniProtKB.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0001759; P:organ induction; IEA:Compara.
 GO:0042473; P:outer ear morphogenesis; IEA:Compara.
 GO:0048339; P:paraxial mesoderm development; IEA:Compara.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
 GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:UniProtKB.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Compara.
 GO:0045787; P:positive regulation of cell cycle; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
 GO:0043406; P:positive regulation of MAP kinase activity; IDA:UniProtKB.
 GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; IEA:Compara.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Compara.
 GO:0045666; P:positive regulation of neuron differentiation; IMP:UniProtKB.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; TAS:UniProtKB.
 GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.
 GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
 GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IEA:Compara.
 GO:0048378; P:regulation of lateral mesodermal cell fate specification; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0048705; P:skeletal system morphogenesis; TAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0001657; P:ureteric bud development; IEA:Compara.
 GO:0021847; P:ventricular zone neuroblast division; IEA:Compara. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016248; Tyr_kinase_fibroblast_GF_rcpt. 
Pfam
 PF07679; I-set
 PF07714; Pkinase_Tyr 
SMART
 SM00408; IGc2
 SM00219; TyrKc 
PROSITE
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.