UniProt Accession

 H1T_RAT; P06349 

Genbank Protein ID

 M13170; M28409 

Genbank Nucleotide ID

 AAA41328.1; AAA41305.1 

Protein Name

 Histone H1t 

Protein Synonyms/Alias

  

Gene Name

 Hist1h1t 

Gene Synonyms/Alias

 H1ft; H1t 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
19	LVPAPVEKPATKRRG	acetylation	[1]
28	ATKRRGKKPGMATAR	acetylation	[1]
66	MSLAALKKALAAAGY	ubiquitination	[2]
77	AAGYDVEKNNSRIKL	ubiquitination	[2]
92	ALKRLVNKGVLVQTK	acetylation	[1]
198	KSKMVMQKTDLRKAA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. 

Sequence Annotation

 DOMAIN 38 111 H15.
 MOD_RES 9 9 Phosphoserine.
 MOD_RES 141 141 Phosphoserine.
 MOD_RES 156 156 Phosphothreonine.
 MOD_RES 178 178 Phosphoserine.
 MOD_RES 187 187 Phosphoserine.  

Keyword

 Chromosome; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Spermatogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 208 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0007283; P:spermatogenesis; IEP:RGD. 

Interpro

 IPR005818; Histone_H1/H5.
 IPR005819; Histone_H5.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00538; Linker_histone 

SMART

 SM00526; H15 

PROSITE

 PS51504; H15 

PRINTS

 PR00624; HISTONEH5.