CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022738
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pericentriolar material 1 protein 
Protein Synonyms/Alias
 PCM-1; mPCM-1 
Gene Name
 Pcm1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
259SYMKFLQKILARDPQubiquitination[1]
393SEHLPDEKVQLFSKMubiquitination[1]
399EKVQLFSKMRVLQEKubiquitination[1]
1073QNNVQRLKQMLTELMubiquitination[1]
1178TEYMAFPKPFESSSSubiquitination[1]
1190SSSLGAEKQRNQKQPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins probably including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Probably involved in the biogenesis of cilia. 
Sequence Annotation
 MOD_RES 65 65 Phosphoserine.
 MOD_RES 68 68 Phosphoserine (By similarity).
 MOD_RES 69 69 Phosphoserine.
 MOD_RES 93 93 Phosphoserine (By similarity).
 MOD_RES 110 110 Phosphoserine (By similarity).
 MOD_RES 399 399 N6-acetyllysine (By similarity).
 MOD_RES 859 859 Phosphoserine (By similarity).
 MOD_RES 864 864 Phosphoserine.
 MOD_RES 957 957 Phosphoserine (By similarity).
 MOD_RES 1182 1182 Phosphoserine (By similarity).
 MOD_RES 1228 1228 Phosphoserine (By similarity).
 MOD_RES 1254 1254 Phosphoserine (By similarity).
 MOD_RES 1257 1257 Phosphoserine (By similarity).
 MOD_RES 1260 1260 Phosphoserine (By similarity).
 MOD_RES 1287 1287 Phosphoserine.
 MOD_RES 1432 1432 Phosphoserine.
 MOD_RES 1434 1434 Phosphoserine.
 MOD_RES 1654 1654 Phosphoserine.
 MOD_RES 1695 1695 Phosphoserine (By similarity).
 MOD_RES 1729 1729 Phosphoserine.
 MOD_RES 1766 1766 Phosphoserine.
 MOD_RES 1769 1769 Phosphoserine.
 MOD_RES 1777 1777 Phosphoserine.
 MOD_RES 1959 1959 Phosphoserine (By similarity).
 MOD_RES 1978 1978 Phosphoserine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2025 AA 
Protein Sequence
MATGGGPFEE VMHDQDLPNW SNDSVDDRLN NMEWGGQQKK ANRSSEKNKK KFGVASDKRV 60
TNAISPESSP GVGRRRTKIP HTFPHSRYMT QMSVPEQAEL EKLKQRINFS DLDQRSIGSD 120
SQGRATAANN KRQLSENRKP FNFLPMQINT NKSKDATASL PKREMTTSAQ CKELFASALS 180
NDLLQNCQVS EEDGRGEPAM ESSQIVSRLV QIRDYITKAS SMREDLVEKN ERSANVERLT 240
HLIEHLKEQE KSYMKFLQKI LARDPQQEPM EETENLKKQH DLLKRMLQQQ EQLRALQGRQ 300
AALLALQHKA EQAIAVMDDS VVTETTGSLS GVSITSELNE ELNDLIQRFH NQLRDSQPPA 360
VPDNRRQAES LSLTREISQS RNPSVSEHLP DEKVQLFSKM RVLQEKKQKM DKLLGELHNL 420
RDQHLNNSSF VPSTSLQRSG DKRSSTVALS APVGFASAVN GEANSLISSV PCPATSLVSQ 480
NESENEGHLN PAEKLQKLNE VQKRLNELRE LVHYYEQTSD MMTDAVNENT KDEETEESEY 540
DSEHENSEPV TNIRNPQVAS TWNEVNTNSN TQCGSNNRDG RPVNSNCEIN NRSAANIRAL 600
NMPPLDCRYN REGEQRLHVA HGEDEEEEVE EEGVSGASLS SRRSSLVDEA PEDEEFEQKI 660
SRLMAAKEKL KQLQDLVAMV QDDDATQVVV PAASNLDDFY AAEEDIKQNS NNARENSNKI 720
DTGVNEKTRE KFYEAKLQQQ QRELKQLQEE RKKLIEIQEK IQAVQKACPD LQLSATSISS 780
GPTKKYLPAI TSTPTVNEND SSTSKCVIDP EDSSVVDNEL WSDMRRHEML REELRQRRKQ 840
LEALMAEHQR RQGLAETSSP VAISLRSDGS ENLCTPQQSR TEKTMATWGG STQCALDEEG 900
DEDGYLSEGI VRTDEEEEEE QDASSNDNFP IYPPSMNQNS YNVKETKTRW KSNRPVSADG 960
NYRPLAKTRQ QNISMQRQEN LRWVSELSYI EEKEQWQEQI NQLKKQLDFS VNICQTLMQD 1020
QQTLSCLLQT LLTGPYSVLP SNVASPQVHL IMHQLNQCYT QLTWQQNNVQ RLKQMLTELM 1080
RQQNQHPEKP RSKERGSSAS HPSSPNLFCP FSFPTQPVNL FNLPGFTNFP SFAPGMNFSP 1140
LFPSNFGDFS QNVSTPTEQQ QPLAQNPSGK TEYMAFPKPF ESSSSLGAEK QRNQKQPEEE 1200
AENTKTPWLY DQEGGVEKPF FKTGFTESVE KATNSNRKNQ PDTSRRRRQF DEESLESFSS 1260
MPDPIDPTTV TKTFKTRKAS AQASLASKDK TPKSKSKKRN STQLKSRVKN IGYESASVSS 1320
TCEPCKNRNR HSAQTEEPVQ AKLFSRKNHE QLEKIIKYSR SAEISSETGS DFSMFEALRD 1380
TIYSEVATLI SQNESRPHFL IELFHELQLL NTDYLRQRAL YALQDIVSRH ISESDEREGE 1440
NVKPVNSGTW VASNSELTPS ESLVTTDDET FEKNFERETH KVSEQNDADN VSVMSVSSNF 1500
EPFATDDLGN TVIHLDQALA RMREYERMKT ETESHSNMRC TCRVIEDEDG AAAAATVSNS 1560
EETPIIENHN SPQPISDVSA VPCPRIDTQQ LDRQIKAIMK EVIPFLKEHM DEVCSSQLLT 1620
SVRRMVLTLT QQNDESKEFV KFFHKQLGSI LQDSLAKFAG RKLKDCGEDL LVEISEVLFN 1680
ELAFFKLMQD LDNNSIAVKQ RCKRKIEAAG VRQSYAKEAK RILEGDHGSP AGEIDDEDKD 1740
KDETETVKQT QTSEVYDAKG PKNVRSDVSD QEEDEESERC PVSINLSKAE SQALTNYGSG 1800
EDENEDEEME DFEESPVDIQ TSLQANTETT EENEHDSQIL QHDLEKTPES TNVPSDQEPT 1860
SKNDQDSSPV KPCYLNILEN EQQLNSATHK DSLTTTDSSK QPEPLPLPLA ASETLVPRVK 1920
EVKSAQETPE SSLAGSPDTE SPVLVNDYEA ESGNISQKSD EEDFVKVEDL PLKLTVYSEE 1980
ELRKKMIEEE QKNHLSGEIC EMQTEELAGN SQILKEPETV GAQSI 2025 
Gene Ontology
 GO:0034451; C:centriolar satellite; IDA:BHF-UCL.
 GO:0031965; C:nuclear membrane; IEA:Compara.
 GO:0000242; C:pericentriolar material; IDA:BHF-UCL.
 GO:0051297; P:centrosome organization; IEA:Compara.
 GO:0042384; P:cilium assembly; ISS:UniProtKB.
 GO:0022027; P:interkinetic nuclear migration; IMP:BHF-UCL.
 GO:0034454; P:microtubule anchoring at centrosome; IMP:MGI.
 GO:0050768; P:negative regulation of neurogenesis; IMP:BHF-UCL.
 GO:0097150; P:neuronal stem cell maintenance; IMP:MGI.
 GO:0071539; P:protein localization to centrosome; IMP:BHF-UCL. 
Interpro
 IPR024138; Pericentriolar_Pcm1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS