CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018801
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Estrogen receptor beta 
Protein Synonyms/Alias
 ER-beta; Nuclear receptor subfamily 3 group A member 2 
Gene Name
 ESR2 
Gene Synonyms/Alias
 ESTRB; NR3A2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
4****MDIKNSPSSLNsumoylation[1]
Reference
 [1] Identification of estrogen receptor β as a SUMO-1 target reveals a novel phosphorylated sumoylation motif and regulation by glycogen synthase kinase 3β.
 Picard N, Caron V, Bilodeau S, Sanchez M, Mascle X, Aubry M, Tremblay A.
 Mol Cell Biol. 2012 Jul;32(14):2709-21. [PMID: 22586270] 
Functional Description
 Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. 
Sequence Annotation
 DNA_BIND 149 214 Nuclear receptor.
 ZN_FING 149 169 NR C4-type.
 ZN_FING 185 209 NR C4-type.
 REGION 1 148 Modulating.
 REGION 215 530 Steroid-binding.
 MOD_RES 87 87 Phosphoserine.
 MOD_RES 105 105 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; DNA-binding; Lipid-binding; Metal-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome; Steroid-binding; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 530 AA 
Protein Sequence
MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS 60
NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN 120
RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 180
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH 240
CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK 300
LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL 360
VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA 420
DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHASN KGMEHLLNMK 480
CKNVVPVYDL LLEMLNAHVL RGCKSSITGS ECSPAEDSKS KEGSQNPQSQ 530 
Gene Ontology
 GO:0005576; C:extracellular region; NAS:GOC.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0001046; F:core promoter sequence-specific DNA binding; IDA:UniProtKB.
 GO:0030284; F:estrogen receptor activity; TAS:UniProtKB.
 GO:0034056; F:estrogen response element binding; IDA:UniProtKB.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; NAS:UniProtKB.
 GO:0048019; F:receptor antagonist activity; NAS:UniProtKB.
 GO:0005496; F:steroid binding; TAS:UniProtKB.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0060743; P:epithelial cell maturation involved in prostate gland development; IEA:Compara.
 GO:0030520; P:intracellular estrogen receptor signaling pathway; TAS:UniProtKB.
 GO:0060766; P:negative regulation of androgen receptor signaling pathway; IEA:Compara.
 GO:0030308; P:negative regulation of cell growth; NAS:UniProtKB.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0060740; P:prostate gland epithelium morphogenesis; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
 GO:0060065; P:uterus development; IEA:Compara.
 GO:0060068; P:vagina development; IEA:Compara. 
Interpro
 IPR021064; Estrogen_rcpt_beta_N.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR024178; Oest_rcpt/oest-rel_rcp.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF12497; ERbeta_N
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.