CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003159
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldose 1-epimerase 
Protein Synonyms/Alias
 Galactose mutarotase; Type-1 mutarotase 
Gene Name
 galM 
Gene Synonyms/Alias
 b0756; JW0739 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
166TYRATVDKPCPVNMTacetylation[1]
191QSDVRNHKLQILADEacetylation[2]
253HAFLLQAKGDGKKVAacetylation[2]
269HVWSADEKLQLKVYTacetylation[2]
Reference
 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose. 
Sequence Annotation
 ACT_SITE 175 175 Proton donor (By similarity).
 ACT_SITE 309 309 Proton acceptor (By similarity).
 BINDING 79 79 Substrate (By similarity).
 BINDING 245 245 Substrate (By similarity).  
Keyword
 Carbohydrate metabolism; Complete proteome; Cytoplasm; Direct protein sequencing; Isomerase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 346 AA 
Protein Sequence
MLNETPALAP DGQPYRLLTL RNNAGMVVTL MDWGATLLSA RIPLSDGSVR EALLGCASPE 60
CYQDQAAFLG ASIGRYANRI ANSRYTFDGE TVTLSPSQGV NQLHGGPEGF DKRRWQIVNQ 120
NDRQVLFALS SDDGDQGFPG NLGATVQYRL TDDNRISITY RATVDKPCPV NMTNHVYFNL 180
DGEQSDVRNH KLQILADEYL PVDEGGIPHD GLKSVAGTSF DFRSAKIIAS EFLADDDQRK 240
VKGYDHAFLL QAKGDGKKVA AHVWSADEKL QLKVYTTAPA LQFYSGNFLG GTPSRGTEPY 300
ADWQGLALES EFLPDSPNHP EWPQPDCFLR PGEEYSSLTE YQFIAE 346 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:EcoCyc.
 GO:0004034; F:aldose 1-epimerase activity; IDA:EcoCyc.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0033499; P:galactose catabolic process via UDP-galactose; IMP:EcoCyc. 
Interpro
 IPR018052; Ald1_epimerase_CS.
 IPR013458; Ald_epimerase_bac.
 IPR015443; Aldose_1-epimerase.
 IPR008183; Aldose_1/G6P_1-epimerase.
 IPR011013; Gal_mutarotase_SF_dom.
 IPR014718; Glyco_hydro-type_carb-bd_sub. 
Pfam
 PF01263; Aldose_epim 
SMART
  
PROSITE
 PS00545; ALDOSE_1_EPIMERASE 
PRINTS