UniProt Accession

 GGA2_HUMAN; Q9UJY4; D3DWF0; O14564; Q9NYN2; Q9UPS2 

Genbank Protein ID

 AF190863; AF233522; AF165531; AC002400; CH471145; CH471145; BC000284; AF323754; AB029003 

Genbank Nucleotide ID

 AAF05708.1; AAF35394.1; AAF42806.1; AAC05813.1; EAW55827.1; EAW55828.1; AAH00284.1; AAK38634.1; BAA83032.1 

Protein Name

 ADP-ribosylation factor-binding protein GGA2 

Protein Synonyms/Alias

 Gamma-adaptin-related protein 2; Golgi-localized, gamma ear-containing, ARF-binding protein 2; VHS domain and ear domain of gamma-adaptin; Vear 

Gene Name

 GGA2 

Gene Synonyms/Alias

 KIAA1080 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
117	LIKVLSPKYLGSWAT	ubiquitination	[1]
200	KLLTRLLKSNHPEDL	ubiquitination	[2, 3]
274	VVYERCEKLRPTLFR	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. 

Sequence Annotation

 DOMAIN 33 163 VHS.
 DOMAIN 188 315 GAT.
 DOMAIN 484 605 GAE.
 REGION 316 483 Unstructured hinge.  

Keyword

 3D-structure; Complete proteome; Endosome; Golgi apparatus; Membrane; Polymorphism; Protein transport; Reference proteome; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 613 AA 

Protein Sequence

Gene Ontology

 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0030136; C:clathrin-coated vesicle; IDA:UniProtKB.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
 GO:0030306; F:ADP-ribosylation factor binding; IDA:UniProtKB.
 GO:0006886; P:intracellular protein transport; NAS:UniProtKB.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 

Interpro

 IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
 IPR008153; Clathrin_g-adaptin_app.
 IPR013041; Coatomer/clathrin_app_Ig-like.
 IPR008942; ENTH_VHS.
 IPR004152; GAT.
 IPR002014; VHS.
 IPR018205; VHS_subgr. 

Pfam

 PF02883; Alpha_adaptinC2
 PF03127; GAT
 PF00790; VHS 

SMART

 SM00809; Alpha_adaptinC2
 SM00288; VHS 

PROSITE

 PS50180; GAE
 PS50909; GAT
 PS50179; VHS 

PRINTS