CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005315
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protease 2 
Protein Synonyms/Alias
 Oligopeptidase B; Protease II 
Gene Name
 ptrB 
Gene Synonyms/Alias
 tlp; b1845; JW1834 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
63ALQDRILKEIIDRIPacetylation[1]
80EVSAPYIKNGYRYRHacetylation[1]
119ETLLDANKRAAHSEFacetylation[1]
214GTPASQDKLIYEEKDacetylation[1]
220DKLIYEEKDDTYYVSacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues. 
Sequence Annotation
 ACT_SITE 532 532 Charge relay system.
 ACT_SITE 617 617 Charge relay system (By similarity).
 ACT_SITE 652 652 Charge relay system (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; Hydrolase; Protease; Reference proteome; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 686 AA 
Protein Sequence
MLPKAARIPH AMTLHGDTRI DNYYWLRDDT RSQPEVLDYL QQENSYGHRV MASQQALQDR 60
ILKEIIDRIP QREVSAPYIK NGYRYRHIYE PGCEYAIYQR QSAFSEEWDE WETLLDANKR 120
AAHSEFYSMG GMAITPDNTI MALAEDFLSR RQYGIRFRNL ETGNWYPELL DNVEPSFVWA 180
NDSWIFYYVR KHPVTLLPYQ VWRHAIGTPA SQDKLIYEEK DDTYYVSLHK TTSKHYVVIH 240
LASATTSEVR LLDAEMADAE PFVFLPRRKD HEYSLDHYQH RFYLRSNRHG KNFGLYRTRM 300
RDEQQWEELI PPRENIMLEG FTLFTDWLVV EERQRGLTSL RQINRKTREV IGIAFDDPAY 360
VTWIAYNPEP ETARLRYGYS SMTTPDTLFE LDMDTGERRV LKQTEVPGFY AANYRSEHLW 420
IVARDGVEVP VSLVYHRKHF RKGHNPLLVY GYGSYGASID ADFSFSRLSL LDRGFVYAIV 480
HVRGGGELGQ QWYEDGKFLK KKNTFNDYLD ACDALLKLGY GSPSLCYAMG GSAGGMLMGV 540
AINQRPELFH GVIAQVPFVD VVTTMLDESI PLTTGEFEEW GNPQDPQYYE YMKSYSPYDN 600
VTAQAYPHLL VTTGLHDSQV QYWEPAKWVA KLRELKTDDH LLLLCTDMDS GHGGKSGRFK 660
SYEGVAMEYA FLVALAQGTL PATPAD 686 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:EcoCyc.
 GO:0004252; F:serine-type endopeptidase activity; IDA:EcoCyc.
 GO:0070008; F:serine-type exopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR002471; Pept_S9_AS.
 IPR023302; Pept_S9A_oligopept_N.
 IPR001375; Peptidase_S9.
 IPR002470; Peptidase_S9A.
 IPR004106; Peptidase_S9A_B_C_N. 
Pfam
 PF00326; Peptidase_S9
 PF02897; Peptidase_S9_N 
SMART
  
PROSITE
 PS00708; PRO_ENDOPEP_SER 
PRINTS
 PR00862; PROLIGOPTASE.