CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019695
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin heavy chain, non-muscle 
Protein Synonyms/Alias
 Myosin II; Non-muscle MHC; Zipper protein 
Gene Name
 zip 
Gene Synonyms/Alias
 CG15792 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
58DRNDPELKYLSVERNacetylation[1]
125ILRDDIQKMNPPKFDacetylation[1]
742RTVSHLYKEQLAKLMacetylation[1]
1680EKRRGLVKQLRDLETacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
 Nonmuscle myosin appears to be responsible for cellularization. Required for morphogenesis and cytokinesis. 
Sequence Annotation
 DOMAIN 1 869 Myosin head-like.
 DOMAIN 870 899 IQ.
 NP_BIND 225 232 ATP.
 REGION 250 260 25 kDa/50 kDa junction.
 REGION 722 734 50 kDa/20 kDa junction.
 REGION 745 767 Actin-binding.
 REGION 782 798 Reactive sulfhydryl/actin-binding.
 REGION 1343 2057 Light meromyosin (LMM).
 REGION 1343 2010 Alpha-helical tailpiece (LMM).
 REGION 2011 2057 Globular tailpiece.
 MOD_RES 2021 2021 Phosphoserine.
 MOD_RES 2022 2022 Phosphoserine.  
Keyword
 Actin-binding; Alternative splicing; ATP-binding; Calmodulin-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2057 AA 
Protein Sequence
MKSAWLALKS KSALHPKSEY PVSNIHYPKA ANYRQTRNYL EIAAKMSEEV DRNDPELKYL 60
SVERNQFNPI RPRRPSGHRS VLVWVPHENQ GFVAASIKRE HGDEVEVELA ETGKRVMILR 120
DDIQKMNPPK FDKVEDMAEL TCLNEASVLH NIKDRYYSGL IYTYSGLFCV VVNPYKKLPI 180
YTEKIMERYK GIKRHEVPPH VFAITDSAYR NMLGDREDQS ILCTGESGAG KTENTKKVIQ 240
FLAYVAASKP KGSGAVPHPA VLINFSVNTN KYIKVKIMAQ NQNQTIEVVN GLKMVEVNSN 300
CQEGELEQQL LQANPILEAF GNAKTVKNDN SSRFGKFIRI NFDASGFISG ANIETYLLEK 360
SRAIRQAKDE RTFHIFYQLL AGATPEQREK FILDDVKSYA FLSNGSLPVP GVDDYAEFQA 420
TVKSMNIMGM TSEDFNSIFR IVSAVLLFGS MKFRQERNND QATLPDNTVA QKIAHLLGLS 480
VTDMTRAFLT PRIKVGRDFV TKAQTKEQVE FAVEAIAKAC YERMFKWLVN RINRSLDRTK 540
RQGASFIGIL DMAGFEIFEL NSFEQLCINY TNEKLQQLFN HTMFILEQEE YQREGIEWKF 600
IDFGLDLQPT IDLIDKPGGI MALLDEECWF PKATDKTFVD KLVSAHSMHP KFMKTDFRGV 660
ADFAIVHYAG RVDYSAAKWL MKNMDPLNEN IVSLLQGSQD PFVVNIWKDA EIVGMAQQAL 720
TDTQFGARTR KGMFRTVSHL YKEQLAKLMD TLRNTNPNFV RCIIPNHEKR AGKIDAPLVL 780
DQLRCNGVLE GIRICRQGFP NRIPFQEFRQ RYELLTPNVI PKGFMDGKKA CEKMIQALEL 840
DSNLYRVGQS KIFFRAGVLA HLEEERDFKI SDLIVNFQAF CRGFLARRNY QKRLQQLNAI 900
RIIQRNCAAY LKLRNWQWWR LYTKVKPLLE VTKQEEKLVQ KEDELKQVRE KLDTLAKNTQ 960
EYERKYQQAL VEKTTLAEQL QAEIELCAEA EESRSRLMAR KQELEDMMQE LETRIEEEEE 1020
RVLALGGEKK KLELNIQDLE EQLEEEEAAR QKLQLEKVQL DAKIKKYEED LALTDDQNQK 1080
LLKEKKLLEE RANDLSQTLA EEEEKAKHLA KLKAKHEATI TELEERLHKD QQQRQESDRS 1140
KRKIETEVAD LKEQLNERRV QVDEMQAQLA KREEELTQTL LRIDEESATK ATAQKAQREL 1200
ESQLAEIQED LEAEKAARAK AEKVRRDLSE ELEALKNELL DSLDTTAAQQ ELRSKREQEL 1260
ATLKKSLEEE TVNHEGVLAD MRHKHSQELN SINDQLENLR KAKTVLEKAK GTLEAENADL 1320
ATELRSVNSS RQENDRRRKQ AESQIAELQV KLAEIERARS ELQEKCTKLQ QEAENITNQL 1380
EEAELKASAA VKSASNMESQ LTEAQQLLEE ETRQKLGLSS KLRQIESEKE ALQEQLEEDD 1440
EAKRNYERKL AEVTTQMQEI KKKAEEDADL AKELEEGKKR LNKDIEALER QVKELIAQND 1500
RLDKSKKKIQ SELEDATIEL EAQRTKVLEL EKKQKNFDKI LAEEKAISEQ IAQERDTAER 1560
EAREKETKVL SVSRELDEAF DKIEDLENKR KTLQNELDDL ANTQGTADKN VHELEKAKRA 1620
LESQLAELKA QNEELEDDLQ LTEDAKLRLE VNMQALRSQF ERDLLAKEEG AEEKRRGLVK 1680
QLRDLETELD EERKQRTAAV ASKKKLEGDL KEIETTMEMH NKVKEDALKH AKKLQAQVKD 1740
ALRDAEEAKA AKEELQALSK EADGKVKALE AEVLQLTEDL ASSERARRAA ETERDELAEE 1800
IANNANKGSL MIDEKRRLEA RIATLEEELE EEQSNSEVLL DRSRKAQLQI EQLTTELANE 1860
KSNSQKNENG RALLERQNKE LKAKLAEIET AQRTKVKATI ATLEAKIANL EEQLENEGKE 1920
RLLQQKANRK MDKKIKELTM NIEDERRHVD QHKEQMDKLN SRIKLLKRNL DETEEELQKE 1980
KTQKRKYQRE CEDMIESQEA MNREINSLKT KLRRTGGIGL SSSRLTGTPS SKRAGGGGGS 2040
DDSSVQDESL DGEDSAN 2057 
Gene Ontology
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00612; IQ
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.