UniProt Accession

 MS18B_HUMAN; O43482; Q96BX7 

Genbank Protein ID

 AF025441; BC015050 

Genbank Nucleotide ID

 AAC39561.1; AAH15050.1 

Protein Name

 Protein Mis18-beta 

Protein Synonyms/Alias

 Cancer/testis antigen 86; CT86; Opa-interacting protein 5; OIP-5 

Gene Name

 OIP5 

Gene Synonyms/Alias

 MIS18B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
215	NRLKSLMKILSEVTP	ubiquitination	[1, 2]
226	EVTPDQSKPEN****	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. 

Sequence Annotation

 MOD_RES 48 48 Phosphoserine.
 MOD_RES 221 221 Phosphothreonine.
 MOD_RES 225 225 Phosphoserine.  

Keyword

 Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Mitosis; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IDA:MGI.
 GO:0000785; C:chromatin; IDA:MGI.
 GO:0010369; C:chromocenter; IEA:Compara.
 GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
 GO:0007154; P:cell communication; NAS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0034080; P:CENP-A containing nucleosome assembly at centromere; TAS:Reactome.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW. 

Interpro

  

Pfam

  

SMART

  

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PRINTS