| Tag | Content |
|---|
| CPLM ID | CPLM-017332 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DBIRD complex subunit KIAA1967 |
Protein Synonyms/Alias | Deleted in breast cancer gene 1 protein; DBC-1; DBC.1; p30 DBC |
Gene Name | KIAA1967 |
Gene Synonyms/Alias | DBC1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 123 | LSNQPLLKSPAPPLL | ubiquitination | [1] | | 287 | RIQVSSEKEAAPDAG | ubiquitination | [1] | | 309 | SDPAYSSKVLLLSSP | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. |
Sequence Annotation | MOD_RES 35 35 Phosphothreonine.
MOD_RES 124 124 Phosphoserine.
MOD_RES 215 215 N6-acetyllysine.
MOD_RES 675 675 Phosphoserine.
MOD_RES 678 678 Phosphoserine.
MOD_RES 681 681 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Metalloenzyme inhibitor; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 923 AA |
Protein Sequence | MSQFKRQRIN PLPGGRNFSG TASTSLLGPP PGLLTPPVAT ELSQNARHLQ GGEKQRVFTG 60
IVTSLHDYFG VVDEEVFFQL SVVKGRLPQL GEKVLVKAAY NPGQAVPWNA VKVQTLSNQP 120
LLKSPAPPLL HVAALGQKQG ILGAQPQLIF QPHRIPPLFP QKPLSLFQTS HTLHLSHLNR 180
FPARGPHGRL DQGRSDDYDS KKRKQRAGGE PWGAKKPRHD LPPYRVHLTP YTVDSPICDF 240
LELQRRYRSL LVPSDFLSVH LSWLSAFPLS QPFSLHHPSR IQVSSEKEAA PDAGAEPITA 300
DSDPAYSSKV LLLSSPGLEE LYRCCMLFVD DMAEPRETPE HPLKQIKFLL GRKEEEAVLV 360
GGEWSPSLDG LDPQADPQVL VRTAIRCAQA QTGIDLSGCT KWWRFAEFQY LQPGPPRRLQ 420
TVVVYLPDVW TIMPTLEEWE ALCQQKAAEA APPTQEAQGE TEPTEQAPDA LEQAADTSRR 480
NAETPEATTQ QETDTDLPEA PPPPLEPAVI ARPGCVNLSL HGIVEDRRPK ERISFEVMVL 540
AELFLEMLQR DFGYRVYKML LSLPEKVVSP PEPEKEEAAK EEATKEEEAI KEEVVKEPKD 600
EAQNEGPATE SEAPLKEDGL LPKPLSSGGE EEEKPRGEAS EDLCEMALDP ELLLLRDDGE 660
EEFAGAKLED SEVRSVASNQ SEMEFSSLQD MPKELDPSAV LPLDCLLAFV FFDANWCGYL 720
HRRDLERILL TLGIRLSAEQ AKQLVSRVVT QNICQYRSLQ YSRQEGLDGG LPEEVLFGNL 780
DLLPPPGKST KPGAAPTEHK ALVSHNGSLI NVGSLLQRAE QQDSGRLYLE NKIHTLELKL 840
EESHNRFSAT EVTNKTLAAE MQELRVRLAE AEETARTAER QKSQLQRLLQ ELRRRLTPLQ 900
LEIQRVVEKV RWGWTRRQHS SFP 923 |
Gene Ontology | GO:0044609; C:DBIRD complex; IDA:UniProtKB. GO:0005759; C:mitochondrial matrix; IDA:UniProtKB. GO:0005634; C:nucleus; IDA:UniProtKB. GO:0004857; F:enzyme inhibitor activity; IDA:UniProtKB. GO:0000993; F:RNA polymerase II core binding; IDA:UniProtKB. GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IDA:UniProtKB. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB. GO:0032784; P:regulation of DNA-dependent transcription, elongation; IMP:UniProtKB. GO:0008380; P:RNA splicing; IMP:UniProtKB. |
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Pfam | |
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PROSITE | |
PRINTS | |