| Tag | Content |
|---|
| CPLM ID | CPLM-006947 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrin alpha-E |
Protein Synonyms/Alias | HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD103; Integrin alpha-E light chain; Integrin alpha-E heavy chain |
Gene Name | ITGAE |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1022 | GLQVVAVKKLTRTQA | ubiquitination | [1] |
|
Reference | [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. [ PMID: 22505724] |
Functional Description | Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. |
Sequence Annotation | REPEAT 22 79 FG-GAP 1.
REPEAT 80 138 FG-GAP 2.
DOMAIN 200 389 VWFA.
REPEAT 390 442 FG-GAP 3.
REPEAT 447 501 FG-GAP 4.
REPEAT 502 560 FG-GAP 5.
REPEAT 563 627 FG-GAP 6.
REPEAT 631 691 FG-GAP 7.
REGION 145 199 X-domain (extra domain).
MOTIF 1150 1154 GFFKR motif.
CARBOHYD 49 49 N-linked (GlcNAc...) (Potential).
CARBOHYD 271 271 N-linked (GlcNAc...) (Potential).
CARBOHYD 321 321 N-linked (GlcNAc...) (Potential).
CARBOHYD 444 444 N-linked (GlcNAc...) (Potential).
CARBOHYD 726 726 N-linked (GlcNAc...) (Potential).
CARBOHYD 782 782 N-linked (GlcNAc...) (Potential).
CARBOHYD 857 857 N-linked (GlcNAc...) (Potential).
CARBOHYD 934 934 N-linked (GlcNAc...) (Potential).
CARBOHYD 954 954 N-linked (GlcNAc...) (Potential).
CARBOHYD 1065 1065 N-linked (GlcNAc...) (Potential).
CARBOHYD 1096 1096 N-linked (GlcNAc...) (Potential).
DISULFID 70 79 By similarity.
DISULFID 126 159 By similarity.
DISULFID 706 762 By similarity.
DISULFID 823 829 By similarity.
DISULFID 893 907 By similarity.
DISULFID 1008 1033 By similarity.
DISULFID 1041 1057 By similarity. |
Keyword | Calcium; Cell adhesion; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Integrin; Magnesium; Membrane; Metal-binding; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1179 AA |
Protein Sequence | MWLFHTLLCI ASLALLAAFN VDVARPWLTP KGGAPFVLSS LLHQDPSTNQ TWLLVTSPRT 60
KRTPGPLHRC SLVQDEILCH PVEHVPIPKG RHRGVTVVRS HHGVLICIQV LVRRPHSLSS 120
ELTGTCSLLG PDLRPQAQAN FFDLENLLDP DARVDTGDCY SNKEGGGEDD VNTARQRRAL 180
EKEEEEDKEE EEDEEEEEAG TEIAIILDGS GSIDPPDFQR AKDFISNMMR NFYEKCFECN 240
FALVQYGGVI QTEFDLRDSQ DVMASLARVQ NITQVGSVTK TASAMQHVLD SIFTSSHGSR 300
RKASKVMVVL TDGGIFEDPL NLTTVINSPK MQGVERFAIG VGEEFKSART ARELNLIASD 360
PDETHAFKVT NYMALDGLLS KLRYNIISME GTVGDALHYQ LAQIGFSAQI LDERQVLLGA 420
VGAFDWSGGA LLYDTRSRRG RFLNQTAAAA ADAEAAQYSY LGYAVAVLHK TCSLSYIAGA 480
PRYKHHGAVF ELQKEGREAS FLPVLEGEQM GSYFGSELCP VDIDMDGSTD FLLVAAPFYH 540
VHGEEGRVYV YRLSEQDGSF SLARILSGHP GFTNARFGFA MAAMGDLSQD KLTDVAIGAP 600
LEGFGADDGA SFGSVYIYNG HWDGLSASPS QRIRASTVAP GLQYFGMSMA GGFDISGDGL 660
ADITVGTLGQ AVVFRSRPVV RLKVSMAFTP SALPIGFNGV VNVRLCFEIS SVTTASESGL 720
REALLNFTLD VDVGKQRRRL QCSDVRSCLG CLREWSSGSQ LCEDLLLMPT EGELCEEDCF 780
SNASVKVSYQ LQTPEGQTDH PQPILDRYTE PFAIFQLPYE KACKNKLFCV AELQLATTVS 840
QQELVVGLTK ELTLNINLTN SGEDSYMTSM ALNYPRNLQL KRMQKPPSPN IQCDDPQPVA 900
SVLIMNCRIG HPVLKRSSAH VSVVWQLEEN AFPNRTADIT VTVTNSNERR SLANETHTLQ 960
FRHGFVAVLS KPSIMYVNTG QGLSHHKEFL FHVHGENLFG AEYQLQICVP TKLRGLQVVA 1020
VKKLTRTQAS TVCTWSQERA CAYSSVQHVE EWHSVSCVIA SDKENVTVAA EISWDHSEEL 1080
LKDVTELQIL GEISFNKSLY EGLNAENHRT KITVVFLKDE KYHSLPIIIK GSVGGLLVLI 1140
VILVILFKCG FFKRKYQQLN LESIRKAQLK SENLLEEEN 1179 |
Gene Ontology | GO:0009897; C:external side of plasma membrane; IEA:Compara. GO:0008305; C:integrin complex; TAS:ProtInc. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |