CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015489
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat-containing protein 88 
Protein Synonyms/Alias
 PQQ repeat and WD repeat-containing protein 
Gene Name
 WDR88 
Gene Synonyms/Alias
 PQWD 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
360GYRKLSLKGHNDWVMacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 REPEAT 100 139 WD 1.
 REPEAT 143 182 WD 2.
 REPEAT 184 224 WD 3.
 REPEAT 228 267 WD 4.
 REPEAT 271 310 WD 5.
 REPEAT 319 358 WD 6.
 REPEAT 361 400 WD 7.  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 472 AA 
Protein Sequence
MASPPRCSPT AHDRECKLPP PSAPASEYCP GKLSWGTMAR ALGRFKLSIP HTHLLATLDP 60
LALDREPPPH LLPEKHQVPE KLIWGDQDPL SKIPFKILSG HEHAVSTCHF CVDDTKLLSG 120
SYDCTVKLWD PVDGSVVRDF EHRPKAPVVE CSITGDSSRV IAASYDKTVR AWDLETGKLL 180
WKVRYDTFIV SCKFSPDGKY VVSGFDVDHG ICIMDAENIT TVSVIKDHHT RSITSCCFDP 240
DSQRVASVSL DRCIKIWDVT SQATLLTITK AHSNAISNCC FTFSGHFLCT SSWDKNLKIW 300
NVHTGEFRNC GACVTLMQGH EGSVSSCHFA RDSSFLISGG FDRTVAIWDV AEGYRKLSLK 360
GHNDWVMDVA ISNNKKWILS ASKDRTMRLW NIEEIDEIPL VIKYKKAVGL KLKQCERCDR 420
PFSIFKSDTS SEMFTQCVFC RIDTRGLPAD TSSSSSSSER ENSPPPRGSK DD 472 
Gene Ontology
  
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR018391; PQQ_beta_propeller_repeat.
 IPR002372; PQQ_repeat.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF01011; PQQ
 PF00400; WD40 
SMART
 SM00564; PQQ
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.