UniProt Accession

 1433S_MOUSE; O70456; Q3TEZ1 

Genbank Protein ID

 AF058798; AK146490; AK169358; AL627228; CH466552 

Genbank Nucleotide ID

 AAC14344.1; BAE27209.1; BAE41107.1; CAM14836.1; EDL30056.1 

Protein Name

 14-3-3 protein sigma 

Protein Synonyms/Alias

 Stratifin 

Gene Name

 Sfn 

Gene Synonyms/Alias

 Mkrn3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
11	ASLIQKAKLAEQAER	ubiquitination	[1]
122	ESRVFYLKMKGDYYR	ubiquitination	[1]
124	RVFYLKMKGDYYRYL	acetylation	[2]
124	RVFYLKMKGDYYRYL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. 

Sequence Annotation

 MOD_RES 5 5 Phosphoserine (By similarity).
 MOD_RES 64 64 Phosphoserine.
 MOD_RES 216 216 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Secreted. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0019901; F:protein kinase binding; IDA:UniProtKB.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Compara.
 GO:0030216; P:keratinocyte differentiation; IMP:MGI.
 GO:0043616; P:keratinocyte proliferation; IGI:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IDA:UniProtKB.
 GO:0046827; P:positive regulation of protein export from nucleus; IDA:UniProtKB.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:MGI.
 GO:0001836; P:release of cytochrome c from mitochondria; IEA:Compara.
 GO:0043588; P:skin development; IMP:MGI. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1
 PS00797; 1433_2 

PRINTS

 PR00305; 1433ZETA.