Tag | Content |
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CPLM ID | CPLM-024053 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Claudin-3 |
Protein Synonyms/Alias | Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2 |
Gene Name | Cldn3 |
Gene Synonyms/Alias | Cpetr2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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194 | RDKYAPTKILYSAPR | ubiquitination | [1] | 216 | TGTAYDRKDYV**** | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. |
Sequence Annotation | REGION 218 219 Interactions with TJP1, TJP2 and TJP3 (By MOD_RES 203 203 Phosphothreonine. |
Keyword | Alternative splicing; Cell junction; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 219 AA |
Protein Sequence | MSMGLEITGT SLAVLGWLCT IVCCALPMWR VSAFIGSSII TAQITWEGLW MNCVVQSTGQ 60 MQCKMYDSLL ALPQDLQAAR ALIVVSILLA AFGLLVALVG AQCTNCVQDE TAKAKITIVA 120 GVLFLLAALL TLVPVSWSAN TIIRDFYNPL VPEAQKREMG AGLYVGWAAA ALQLLGGALL 180 CCSCPPRDKY APTKILYSAP RSTGPGTGTG TAYDRKDYV 219 |
Gene Ontology | GO:0016021; C:integral to membrane; NAS:UniProtKB. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005923; C:tight junction; IDA:UniProtKB. GO:0005198; F:structural molecule activity; IEA:InterPro. GO:0016338; P:calcium-independent cell-cell adhesion; IDA:UniProtKB. GO:0001666; P:response to hypoxia; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |