CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020783
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dystrobrevin alpha 
Protein Synonyms/Alias
 DTN-A; Alpha-dystrobrevin 
Gene Name
 Dtna 
Gene Synonyms/Alias
 Dtn 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
7*MIEDSGKRGNTMAEubiquitination[1]
202RSCFSQQKKVTLNGFubiquitination[1]
305KLTNALSKSLSCASSubiquitination[1]
374DSEVEQNKMLARAAPubiquitination[1]
385RAAPAFLKGRGIQYSubiquitination[1]
467SFTIDANKQQRQLIAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in synapse maturation and required for normal muscle function. 
Sequence Annotation
 ZN_FING 237 284 ZZ-type.
 REGION 1 288 Interaction with MAGEE1.
 REGION 397 447 Syntrophin-binding region.  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Synapse; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 746 AA 
Protein Sequence
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE 60
ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH QIHVEQSISL LLNFLLAAFD 120
PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA 180
VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP 240
VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 300
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS VPSSGSPFIT 360
RSSPPKDSEV EQNKMLARAA PAFLKGRGIQ YSLNVADRLA DEHVLIGLYV NMLRNDPPCM 420
LESSNRLDEE HRLIARYAAR LAAESSSSQP TQQRSAPDIS FTIDANKQQR QLIAELENKN 480
REILQEIQRL RVEHEQASQP TPEKAQQNPT LLAELRLLRQ RKDELEQRMS ALQESRRELM 540
VQLEGLMKLL KEEELKQGTQ GASSPRSSPS HTISRPIPMP IRSASACPTP THTPQDSLTG 600
VGGDVQEAFA QSSRRNLRSD LLVAADSITN TMSSLVKELN SEVASETEST VDSEFSRPQF 660
EDLAPSPTSE KAFLAQIHSR KPGYIHGGAA STTHGDMVPE DGDPYTQPED GNYENESVRQ 720
LENELQLEEY LKQKLQDEAY QVSLQG 746 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016014; C:dystrobrevin complex; NAS:UniProtKB.
 GO:0042383; C:sarcolemma; TAS:MGI.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR017432; Distrobrevin.
 IPR011992; EF-hand-like_dom.
 IPR015153; EF-hand_dom_typ1.
 IPR015154; EF-hand_dom_typ2.
 IPR000433; Znf_ZZ. 
Pfam
 PF09068; efhand_1
 PF09069; efhand_2
 PF00569; ZZ 
SMART
 SM00291; ZnF_ZZ 
PROSITE
 PS01357; ZF_ZZ_1
 PS50135; ZF_ZZ_2 
PRINTS