UniProt Accession

 PMEPA_HUMAN; Q969W9; Q5TDR6; Q8NER4; Q96B72; Q9UJD3 

Genbank Protein ID

 AF224278; AF305616; AY128643; AF305426; AL035541; AL121913; AL121913; AL035541; AL121913; AL035541; AL035541; AL121913; CH471077; CH471077; BC015918 

Genbank Nucleotide ID

 AAF86322.1; AAL16781.1; AAM89277.1; AAL09357.1; CAI23105.1; CAI23105.1; CAI19031.1; CAI19031.1; CAM27272.1; CAM27272.1; CAM28295.1; CAM28295.1; EAW75505.1; EAW75508.1; AAH15918.2 

Protein Name

 Transmembrane prostate androgen-induced protein 

Protein Synonyms/Alias

 Solid tumor-associated 1 protein 

Gene Name

 PMEPA1 

Gene Synonyms/Alias

 STAG1; TMEPAI 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
277	ESAAIWSKEKDKQKG	ubiquitination	[1, 2]
279	AAIWSKEKDKQKGHP	ubiquitination	[3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4. 

Sequence Annotation

 MOTIF 158 161 WW-binding 1.
 MOTIF 229 232 WW-binding 2.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Membrane; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 287 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0030521; P:androgen receptor signaling pathway; NAS:UniProtKB.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; TAS:Reactome.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome. 

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