UniProt Accession

 AMRP_MOUSE; P55302 

Genbank Protein ID

 S67967; D00622 

Genbank Nucleotide ID

 AAC60668.1; BAA00500.1 

Protein Name

 Alpha-2-macroglobulin receptor-associated protein 

Protein Synonyms/Alias

 Alpha-2-MRAP; Heparin-binding protein 44; HBP-44; Low density lipoprotein receptor-related protein-associated protein 1; RAP 

Gene Name

 Lrpap1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
131	RYGLDGRKDAQMVHS	ubiquitination	[1]
185	EFLHYKEKIQEYNVL	ubiquitination	[1]
223	KSDTLISKHSELKDR	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. 

Sequence Annotation

 REGION 240 356 LDL receptor binding (Potential).
 MOTIF 357 360 Prevents secretion from ER (Potential).
 CARBOHYD 271 271 N-linked (GlcNAc...) (Potential).  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Heparin-binding; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
 GO:0005576; C:extracellular region; IEA:Compara.
 GO:0005886; C:plasma membrane; ISO:MGI.
 GO:0048237; C:rough endoplasmic reticulum lumen; IEA:Compara.
 GO:0031982; C:vesicle; IEA:Compara.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0050750; F:low-density lipoprotein particle receptor binding; ISO:MGI.
 GO:1900116; P:extracellular negative regulation of signal transduction; IEA:Compara.
 GO:1900222; P:negative regulation of beta-amyloid clearance; IEA:Compara.
 GO:0032091; P:negative regulation of protein binding; IEA:Compara.
 GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Compara. 

Interpro

 IPR010483; Alpha_2_MRAP_C.
 IPR009066; MG_RAP_rcpt_1. 

Pfam

 PF06401; Alpha-2-MRAP_C
 PF06400; Alpha-2-MRAP_N 

SMART

  

PROSITE

 PS00014; ER_TARGET 

PRINTS