| Tag | Content |
|---|
| CPLM ID | CPLM-018827 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone-lysine N-methyltransferase EZH1 |
Protein Synonyms/Alias | ENX-2; Enhancer of zeste homolog 1 |
Gene Name | EZH1 |
Gene Synonyms/Alias | KIAA0388 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 576 | CKTQCNTKQCPCYLA | ubiquitination | [1] | | 720 | HRIGIFAKRAIQAGE | ubiquitination | [1] | | 742 | YSQADALKYVGIERE | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. |
Sequence Annotation | DOMAIN 504 606 CXC.
DOMAIN 613 728 SET.
MOTIF 491 496 Nuclear localization signal (Potential). |
Keyword | Alternative splicing; Chromatin regulator; Complete proteome; Methyltransferase; Nucleus; Reference proteome; Repressor; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 747 AA |
Protein Sequence | MEDYSKMEIP NPPTSKCITY WKRKVKSEYM RLRQLKRLQA NMGAKALYVA NFAKVQEKTQ 60
ILNEEWKKLR VQPVQSMKPV SGHPFLKKCT IESIFPGFAS QHMLMRSLNT VALVPIMYSW 120
SPLQQNFMVE DETVLCNIPY MGDEVKEEDE TFIEELINNY DGKVHGEEEM IPGSVLISDA 180
VFLELVDALN QYSDEEEEGH NDTSDGKQDD SKEDLPVTRK RKRHAIEGNK KSSKKQFPND 240
MIFSAIASMF PENGVPDDMK ERYRELTEMS DPNALPPQCT PNIDGPNAKS VQREQSLHSF 300
HTLFCRRCFK YDCFLHPFHA TPNVYKRKNK EIKIEPEPCG TDCFLLLEGA KEYAMLHNPR 360
SKCSGRRRRR HHIVSASCSN ASASAVAETK EGDSDRDTGN DWASSSSEAN SRCQTPTKQK 420
ASPAPPQLCV VEAPSEPVEW TGAEESLFRV FHGTYFNNFC SIARLLGTKT CKQVFQFAVK 480
ESLILKLPTD ELMNPSQKKK RKHRLWAAHC RKIQLKKDNS STQVYNYQPC DHPDRPCDST 540
CPCIMTQNFC EKFCQCNPDC QNRFPGCRCK TQCNTKQCPC YLAVRECDPD LCLTCGASEH 600
WDCKVVSCKN CSIQRGLKKH LLLAPSDVAG WGTFIKESVQ KNEFISEYCG ELISQDEADR 660
RGKVYDKYMS SFLFNLNNDF VVDATRKGNK IRFANHSVNP NCYAKVVMVN GDHRIGIFAK 720
RAIQAGEELF FDYRYSQADA LKYVGIERET DVL 753 |
Gene Ontology | GO:0035098; C:ESC/E(Z) complex; IDA:UniProtKB. GO:0003682; F:chromatin binding; TAS:ProtInc. GO:0046976; F:histone methyltransferase activity (H3-K27 specific); IEA:Compara. GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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