UniProt Accession

 BEX3_HUMAN; Q00994; B2RD17; D3DXA3; Q5JQT4; Q5JQT5 

Genbank Protein ID

 M38188; AF187064; AY833562; AK315371; EL953547; AL606763; CH471190; CH471190; BC003190 

Genbank Nucleotide ID

 AAA63232.1; AAF75129.1; AAX40680.1; BAG37764.1; EAW54710.1; EAW54712.1; AAH03190.1 

Protein Name

 Protein BEX3 

Protein Synonyms/Alias

 Brain-expressed X-linked protein 3; Nerve growth factor receptor-associated protein 1; Ovarian granulosa cell 13.0 kDa protein HGR74; p75NTR-associated cell death executor 

Gene Name

 NGFRAP1 

Gene Synonyms/Alias

 BEX3; DXS6984E; NADE 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
80	EMREIRRKLRELQLR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases. 

Sequence Annotation

 REGION 68 111 Interaction with 14-3-3 epsilon (By
 REGION 68 93 Interaction with p75NTR/NGFR (By
 MOTIF 77 87 Nuclear export signal (By similarity).  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 111 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; TAS:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0097190; P:apoptotic signaling pathway; TAS:Reactome.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome. 

Interpro

 IPR007623; BEX.
 IPR021156; TF_A-like/BEX-like. 

Pfam

 PF04538; BEX 

SMART

  

PROSITE

  

PRINTS