CPLM-024022

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-024022

UniProt Accession

S4A7_HUMAN; Q9Y6M7; A6NIA8; B2CI53; B5M451; B5M452; B5M453; B6DY52; B6DY53; C9JST9; O60350; Q6AHZ9; Q9HC88; Q9UIB9

Genbank Protein ID

AB012130; AF047033; AF089726; AF053755; EU499349; EU934248; EU934249; EU934250; FJ178574; FJ178575; FJ178576; GU354307; CR627428; AC099535; CH471055

Genbank Nucleotide ID

BAA25898.1; AAD38322.1; AAG16773.1; AAF21720.1; ACB47400.1; ACH61960.1; ACH61961.1; ACH61962.1; ACI24740.1; ACI24741.1; ACI24742.1; ADC32649.1; CAH10515.1; EAW64382.1

Protein Name

Sodium bicarbonate cotransporter 3

Protein Synonyms/Alias

Sodium bicarbonate cotransporter 2; Sodium bicarbonate cotransporter 2b; Bicarbonate transporter; Solute carrier family 4 member 7

Gene Name

SLC4A7

Gene Synonyms/Alias

BT; NBC2; NBC2B; NBC3; SBC2; SLC4A6

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
28	IIFSTKDKLCYRDGE	ubiquitination	[1]
40	DGEEYEWKETARWLK	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.

Sequence Annotation

REGION 1134 1136 CA2-binding.
MOTIF 1211 1214 PDZ-binding.
MOD_RES 233 233 Phosphoserine (By similarity).
MOD_RES 242 242 Phosphoserine.
MOD_RES 379 379 Phosphoserine (By similarity).
MOD_RES 403 403 Phosphoserine.
MOD_RES 407 407 Phosphoserine (By similarity).
MOD_RES 1167 1167 Phosphothreonine.
MOD_RES 1176 1176 Phosphoserine.
MOD_RES 1213 1213 Phosphoserine.
CARBOHYD 171 171 N-linked (GlcNAc...) (Potential).
CARBOHYD 269 269 N-linked (GlcNAc...) (Potential).
CARBOHYD 398 398 N-linked (GlcNAc...) (Potential).
CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
CARBOHYD 776 776 N-linked (GlcNAc...).
CARBOHYD 786 786 N-linked (GlcNAc...).
CARBOHYD 791 791 N-linked (GlcNAc...).

Keyword

Alternative splicing; Cell membrane; Cell projection; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1214 AA

Protein Sequence

MAVTQFIHFR EEIMGNMFFI IIFSTKDKLC YRDGEEYEWK ETARWLKFEE DVEDGGDRWS 60
KPYVATLSLH SLFELRSCIL NGTVMLDMRA STLDEIADMV LDNMIASGQL DESIRENVRE 120
ALLKRHHHQN EKRFTSRIPL VRSFADIGKK HSDPHLLERN GILASPQSAP GNLDNSKSGE 180
IKGNGSGGSR ENSTVDFSKV DMNFMRKIPT GAEASNVLVG EVDFLERPII AFVRLAPAVL 240
LTGLTEVPVP TRFLFLLLGP AGKAPQYHEI GRSIATLMTD EIFHDVAYKA KDRNDLLSGI 300
DEFLDQVTVL PPGEWDPSIR IEPPKSVPSQ EKRKIPVFHN GSTPTLGETP KEAAHHAGPE 360
LQRTGRLFGG LILDIKRKAP FFLSDFKDAL SLQCLASILF LYCACMSPVI TFGGLLGEAT 420
EGRISAIESL FGASLTGIAY SLFAGQPLTI LGSTGPVLVF EKILYKFCRD YQLSYLSLRT 480
SIGLWTSFLC IVLVATDASS LVCYITRFTE EAFAALICII FIYEALEKLF DLGETYAFNM 540
HNNLDKLTSY SCVCTEPPNP SNETLAQWKK DNITAHNISW RNLTVSECKK LRGVFLGSAC 600
GHHGPYIPDV LFWCVILFFT TFFLSSFLKQ FKTKRYFPTK VRSTISDFAV FLTIVIMVTI 660
DYLVGVPSPK LHVPEKFEPT HPERGWIISP LGDNPWWTLL IAAIPALLCT ILIFMDQQIT 720
AVIINRKEHK LKKGAGYHLD LLMVGVMLGV CSVMGLPWFV AATVLSISHV NSLKVESECS 780
APGEQPKFLG IREQRVTGLM IFILMGLSVF MTSVLKFIPM PVLYGVFLYM GVSSLKGIQL 840
FDRIKLFGMP AKHQPDLIYL RYVPLWKVHI FTVIQLTCLV LLWVIKVSAA AVVFPMMVLA 900
LVFVRKLMDL CFTKRELSWL DDLMPESKKK KEDDKKKKEK EEAERMLQDD DDTVHLPFEG 960
GSLLQIPVKA LKYSGDPSIG NISDEMAKTA QWKALSMNTE NAKVTRSNMS PDKPVSVK 1018

Gene Ontology

GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral to membrane; NAS:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
GO:0008510; F:sodium:bicarbonate symporter activity; NAS:UniProtKB.
GO:0060117; P:auditory receptor cell development; IEA:Compara.
GO:0021747; P:cochlear nucleus development; IEA:Compara.
GO:0061299; P:retina vasculature morphogenesis in camera-type eye; IEA:Compara.
GO:0046666; P:retinal cell programmed cell death; IEA:Compara.

Interpro

IPR013769; Band3_cytoplasmic_dom.
IPR011531; HCO3_transpt_C.
IPR003020; HCO3_transpt_euk.
IPR016152; PTrfase/Anion_transptr.

Pfam

PF07565; Band_3_cyto
PF00955; HCO3_cotransp

SMART

PROSITE

PS00219; ANION_EXCHANGER_1
PS00220; ANION_EXCHANGER_2

PRINTS

PR01231; HCO3TRNSPORT.