UniProt Accession

 GATA4_RAT; P46152 

Genbank Protein ID

 L22761 

Genbank Nucleotide ID

 AAA16159.1 

Protein Name

 Transcription factor GATA-4 

Protein Synonyms/Alias

 DNA-binding protein GATA-GT2; GATA-binding factor 4 

Gene Name

 Gata4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
421	QTSQASSKQDSWNSL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Transcriptional activator. Binds to the upstream sequence of the H(+)/K(+)-ATPase beta gene and to a sequence containing the GATA motif. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement (By similarity). 

Sequence Annotation

 ZN_FING 216 240 GATA-type 1.
 ZN_FING 270 294 GATA-type 2.
 MOD_RES 299 299 N6-methyllysine; by EZH2 (By similarity).  

Keyword

 Activator; Complete proteome; DNA-binding; Metal-binding; Methylation; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 440 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:RGD.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0001158; F:enhancer sequence-specific DNA binding; IDA:UniProtKB.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Compara.
 GO:0001076; F:RNA polymerase II transcription factor binding transcription factor activity; IEA:Compara.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:RGD.
 GO:0008134; F:transcription factor binding; IDA:RGD.
 GO:0008270; F:zinc ion binding; TAS:RGD.
 GO:0003290; P:atrial septum secundum morphogenesis; IEA:Compara.
 GO:0003181; P:atrioventricular valve morphogenesis; IEA:Compara.
 GO:0030509; P:BMP signaling pathway; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0061049; P:cell growth involved in cardiac muscle cell development; IDA:RGD.
 GO:0007267; P:cell-cell signaling; IEA:Compara.
 GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
 GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Compara.
 GO:0048617; P:embryonic foregut morphogenesis; IEA:Compara.
 GO:0035054; P:embryonic heart tube anterior/posterior pattern specification; IEA:Compara.
 GO:0003197; P:endocardial cushion development; IEA:Compara.
 GO:0001706; P:endoderm formation; IEA:Compara.
 GO:0072148; P:epithelial cell fate commitment; IEA:Compara.
 GO:0001702; P:gastrulation with mouth forming second; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0060575; P:intestinal epithelial cell differentiation; IEA:Compara.
 GO:0060464; P:lung lobe formation; IEA:Compara.
 GO:0010507; P:negative regulation of autophagy; IMP:RGD.
 GO:0030513; P:positive regulation of BMP signaling pathway; IDA:BHF-UCL.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD.
 GO:0086004; P:regulation of cardiac muscle cell contraction; IMP:RGD.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IDA:RGD.
 GO:0072520; P:seminiferous tubule development; IEA:Compara.
 GO:0060008; P:Sertoli cell differentiation; IEA:Compara.
 GO:0023019; P:signal transduction involved in regulation of gene expression; IEA:Compara.
 GO:0060395; P:SMAD protein signal transduction; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0035239; P:tube morphogenesis; IEA:Compara.
 GO:0003229; P:ventricular cardiac muscle tissue development; IEA:Compara. 

Interpro

 IPR008013; GATA_N.
 IPR016375; TF_GATA_4/5/6.
 IPR000679; Znf_GATA.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF00320; GATA
 PF05349; GATA-N 

SMART

 SM00401; ZnF_GATA 

PROSITE

 PS00344; GATA_ZN_FINGER_1
 PS50114; GATA_ZN_FINGER_2 

PRINTS

 PR00619; GATAZNFINGER.