| Tag | Content |
|---|
| CPLM ID | CPLM-000293 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Gamma-aminobutyric acid receptor subunit delta |
Protein Synonyms/Alias | GABA(A) receptor subunit delta |
Gene Name | GABRD |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 118 | LDSRFVDKLWLPDTF | ubiquitination | [1] | | 229 | TTELMNFKSAGQFPR | ubiquitination | [1] | | 402 | GVETGETKKEGAARS | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
Sequence Annotation | CARBOHYD 103 103 N-linked (GlcNAc...) (Potential).
CARBOHYD 106 106 N-linked (GlcNAc...) (Potential).
DISULFID 164 178 By similarity. |
Keyword | Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disease mutation; Disulfide bond; Epilepsy; Glycoprotein; Ion channel; Ion transport; Membrane; Polymorphism; Postsynaptic cell membrane; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 452 AA |
Protein Sequence | MDAPARLLAP LLLLCAQQLR GTRAMNDIGD YVGSNLEISW LPNLDGLIAG YARNFRPGIG 60
GPPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL SYNHTNETLG LDSRFVDKLW 120
LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG VILYSIRITS TVACDMDLAK YPMDEQECML 180
DLESYGYSSE DIVYYWSESQ EHIHGLDKLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH 240
FHLRRNRGVY IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS 300
LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK QKAKVKVSRP RAEMDVRNAI 360
VLFSLSAAGV TQELAISRRQ RRVPGNLMGS YRSVGVETGE TKKEGAARSG GQGGIRARLR 420
PIDADTIDIY ARAVFPAAFA AVNVIYWAAY AM 452 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW. GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. GO:0004890; F:GABA-A receptor activity; TAS:ProtInc. GO:0007268; P:synaptic transmission; IEA:Compara. GO:0006810; P:transport; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |