CPLM-001036

Genbank Nucleotide ID

Protein Synonyms/Alias

Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B

Aik2; Aim1; Airk2; Ark2; Stk1; Stk12; Stk5

Mus musculus (Mouse)

Position	Peptide	Type	References
207	KVIHRDIKPENLLLG	sumoylation	[1]

[1] SUMOylation modulates the function of Aurora-B kinase.
Fernández-Miranda G, Pérez de Castro I, Carmena M, Aguirre-Portolés C, Ruchaud S, Fant X, Montoya G, Earnshaw WC, Malumbres M.
J Cell Sci. 2010 Aug 15;123(Pt 16):2823-33. [PMID: 20663916]

Functional Description

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (By similarity).

DOMAIN 82 332 Protein kinase.
NP_BIND 88 96 ATP (By similarity).
ACT_SITE 205 205 Proton acceptor (By similarity).
BINDING 111 111 ATP (By similarity).
MOD_RES 35 35 Phosphothreonine (By similarity).
MOD_RES 237 237 Phosphothreonine; by autocatalysis (By

ATP-binding; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Magnesium; Metal-binding; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0010369; C:chromocenter; IDA:MGI.
GO:0032133; C:chromosome passenger complex; IDA:MGI.
GO:0000780; C:condensed nuclear chromosome, centromeric region; IEA:Compara.
GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO:0000776; C:kinetochore; ISO:MGI.
GO:0030496; C:midbody; IEA:Compara.
GO:0097431; C:mitotic spindle pole; ISO:MGI.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007568; P:aging; IEA:Compara.
GO:0008283; P:cell proliferation; IEA:Compara.
GO:0034644; P:cellular response to UV; ISS:UniProtKB.
GO:0036089; P:cleavage furrow formation; ISS:UniProtKB.
GO:0002903; P:negative regulation of B cell apoptotic process; ISS:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO:0032467; P:positive regulation of cytokinesis; ISS:UniProtKB.
GO:0034501; P:protein localization to kinetochore; ISS:UniProtKB.
GO:0051256; P:spindle midzone assembly involved in mitosis; ISS:UniProtKB.

IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.

PS00107; PROTEIN_KINASE_ATP
PS50011; PROTEIN_KINASE_DOM
PS00108; PROTEIN_KINASE_ST