CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021486
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein NRDE2 homolog 
Protein Synonyms/Alias
  
Gene Name
 NRDE2 
Gene Synonyms/Alias
 C14orf102 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
62PLTRSHLKSESSDESacetylation[1]
76SDTNKKLKQTSRKKKacetylation[1]
201CLGINPKKQCISWEGubiquitination[2]
310ESAALKAKVEEFNRRubiquitination[3]
1029DTITRSAKPLEPWLFubiquitination[3]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
 REPEAT 305 337 HAT 1.
 REPEAT 395 427 HAT 2.
 REPEAT 758 792 HAT 3.
 REPEAT 978 1010 HAT 4.
 REPEAT 1067 1101 HAT 5.  
Keyword
 Coiled coil; Complete proteome; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1164 AA 
Protein Sequence
MALFPAFAGL SEAPDGGSSR KELDWLSNPS FCVGSITSLS QQTEAAPAHV SEGLPLTRSH 60
LKSESSDESD TNKKLKQTSR KKKKEKKKKR KHQHHKKTKR KHGPSSSSRS ETDTDSEKDK 120
PSRGVGGSKK ESEEPNQGNN AAADTGHRFV WLEDIQAVTG ETFRTDKKPD PANWEYKSLY 180
RGDIARYKRK GDSCLGINPK KQCISWEGTS TEKKHSRKQV ERYFTKKSVG LMNIDGVAIS 240
SKTEPPSSEP ISFIPVKDLE DAAPVTTWLN PLGIYDQSTT HWLQGQGPPE QESKQPDAQP 300
DSESAALKAK VEEFNRRVRE NPRDTQLWMA FVAFQDEVMK SPGLYAIEEG EQEKRKRSLK 360
LILEKKLAIL ERAIESNQSS VDLKLAKLKL CTEFWEPSTL VKEWQKLIFL HPNNTALWQK 420
YLLFCQSQFS TFSISKIHSL YGKCLSTLSA VKDGSILSHP ALPGTEEAMF ALFLQQCHFL 480
RQAGHSEKAI SLFQAMVDFT FFKPDSVKDL PTKGQVEFFE PFWDSGEPRA GEKGARGWKA 540
WMHQQERGGW VVINPDEDDD EPEEDDQEIK DKTLPRWQIW LAAERSRDQR HWRPWRPDKT 600
KKQTEEDCED PERQVLFDDI GQSLIRLSSH DLQFQLVEAF LQFLGVPSGF TPPASCLYLA 660
MDENSIFDNG LYDEKPLTFF NPLFSGASCV GRMDRLGYPR WTRGQNREGE EFIRNVFHLV 720
MPLFSGKEKS QLCFSWLQYE IAKVIWCLHT KNKKRLKSQG KNCKKLAKNL LKEPENCNNF 780
CLWKQYAHLE WLLGNTEDAR KVFDTALGMA GSRELKDSDL CELSLLYAEL EVELSPEVRR 840
AATARAVHIL TKLTESSPYG PYTGQVLAVH ILKARKAYEH ALQDCLGDSC VSNPAPTDSC 900
SRLISLAKCF MLFQYLTIGI DAAVQIYEQV FAKLNSSVFP EGSGEGDSAS SQSWTSVLEA 960
ITLMHTSLLR FHMKVSVYPL APLREALSQA LKLYPGNQVL WRSYVQIQNK SHSASKTRRF 1020
FDTITRSAKP LEPWLFAIEA EKLRKRLVET VQRLDGREIH ATIPETGLMH RIQALFENAM 1080
RSDSGSQCPL LWRMYLNFLV SLGNKERSKG VFYKALQNCP WAKVLYLDAV EYFPDEMQEI 1140
LDLMTEKELR VRLPLEELEL LLED 1164 
Gene Ontology
  
Interpro
 IPR013633; NRDE-2.
 IPR011990; TPR-like_helical. 
Pfam
 PF08424; NRDE-2 
SMART
  
PROSITE
  
PRINTS