UniProt Accession

 NDRG4_MOUSE; Q8BTG7; Q6ZPW3; Q923D7 

Genbank Protein ID

 AK090374; AK168873; AK129305; BC006595 

Genbank Nucleotide ID

 BAC41189.1; BAE40691.1; BAC98115.1; AAH06595.1 

Protein Name

 Protein NDRG4 

Protein Synonyms/Alias

 N-myc downstream-regulated gene 4 protein; Protein Ndr4 

Gene Name

 Ndrg4 

Gene Synonyms/Alias

 Kiaa1180; Ndr4 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
223	PGTVPNAKTLRCPVM	acetylation	[1]
223	PGTVPNAKTLRCPVM	ubiquitination	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor- induced ERK1 and ERK2 phosphorylation. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. 

Sequence Annotation

 MOD_RES 298 298 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 352 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. 

Interpro

 IPR004142; Ndr. 

Pfam

 PF03096; Ndr 

SMART

  

PROSITE

  

PRINTS