CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000568
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium- and chloride-dependent taurine transporter 
Protein Synonyms/Alias
 Solute carrier family 6 member 6 
Gene Name
 Slc6a6 
Gene Synonyms/Alias
 Taut 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
6**MATKEKLQCLKDFubiquitination[1]
19DFHKDILKPSPGKSPubiquitination[1]
577GPLRVRIKYLITPREubiquitination[1]
611LMNGALMKPSHVIVEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake. 
Sequence Annotation
 MOD_RES 21 21 Phosphoserine.
 MOD_RES 322 322 Phosphoserine (By similarity).
 CARBOHYD 163 163 N-linked (GlcNAc...) (Potential).
 CARBOHYD 179 179 N-linked (GlcNAc...) (Potential).
 CARBOHYD 190 190 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell membrane; Complete proteome; Glycoprotein; Membrane; Neurotransmitter transport; Phosphoprotein; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 621 AA 
Protein Sequence
MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEADGKPPQ REKWSSKIDF VLSVAGGFVG 60
LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEVI IGQYTSEGGI TCWEKICPLF 120
SGIGYASIVI VSLLNVYYIV ILAWATYYLF HSFQKDLPWA HCNHSWNTPQ CMEDTLRRNE 180
SHWVSLSTAN FTSPVIEFWE RNVLSLSSGI DNPGSLKWDL ALCLLLVWLV CFFCIWKGVR 240
STGKVVYFTA TFPFAMLLVL LVRGLTLPGA GEGIKFYLYP DISRLGDPQV WIDAGTQIFF 300
SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF MAQEQGVDIA 360
DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL DSQFVEVEGQ ITSLVDLYPS 420
FLRKGYRREI FIAILCSISY LLGLTMVTEG GMYVFQLFDY YAASGVCLLW VAFFECFVIA 480
WIYGGDNLYD GIEDMIGYRP GPWMKYSWAV ITPALCVGCF VFSLVKYVPL TYNKVYRYPD 540
WAIGLGWGLA LSSMLCIPLV IVILLCRTEG PLRVRIKYLI TPREPNRWAV EREGATPFHS 600
RVTLMNGALM KPSHVIVETM M 621 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IC:MGI.
 GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro.
 GO:0030977; F:taurine binding; IEA:Compara.
 GO:0005368; F:taurine transmembrane transporter activity; IDA:MGI.
 GO:0005369; F:taurine:sodium symporter activity; IEA:Compara.
 GO:0015734; P:taurine transport; IDA:MGI. 
Interpro
 IPR000175; Na/ntran_symport.
 IPR002434; Na/ntran_symport_taurine. 
Pfam
 PF00209; SNF 
SMART
  
PROSITE
 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 
PRINTS
 PR00176; NANEUSMPORT.
 PR01200; TAUTRANSPORT.