| Tag | Content |
|---|
| CPLM ID | CPLM-011811 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Structural maintenance of chromosomes protein 4 |
Protein Synonyms/Alias | |
Gene Name | SMC4 |
Gene Synonyms/Alias | YLR086W; L9449.5 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 528 | DLTQLLEKERSILDD | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. |
Sequence Annotation | NP_BIND 185 192 ATP (Potential).
REGION 674 848 Flexible hinge.
MOD_RES 43 43 Phosphothreonine.
MOD_RES 113 113 Phosphoserine. |
Keyword | ATP-binding; Cell cycle; Cell division; Chromosome; Coiled coil; Complete proteome; Cytoplasm; DNA condensation; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1418 AA |
Protein Sequence | MSDSPLSKRQ KRKSAQEPEL SLDQGDAEED SQVENRVNLS ENTPEPDLPA LEASYSKSYT 60
PRKLVLSSGE NRYAFSQPTN STTTSLHVPN LQPPKTSSRG RDHKSYSQSP PRSPGRSPTR 120
RLELLQLSPV KNSRVELQKI YDRHQSSSKQ QSRLFINELV LENFKSYAGK QVVGPFHTSF 180
SAVVGPNGSG KSNVIDSMLF VFGFRANKMR QDRLSDLIHK SEAFPSLQSC SVAVHFQYVI 240
DESSGTSRID EEKPGLIITR KAFKNNSSKY YINEKESSYT EVTKLLKNEG IDLDHKRFLI 300
LQGEVENIAQ MKPKAEKESD DGLLEYLEDI IGTANYKPLI EERMGQIENL NEVCLEKENR 360
FEIVDREKNS LESGKETALE FLEKEKQLTL LRSKLFQFKL LQSNSKLAST LEKISSSNKD 420
LEDEKMKFQE SLKKVDEIKA QRKEIKDRIS SCSSKEKTLV LERRELEGTR VSLEERTKNL 480
VSKMEKAEKT LKSTKHSISE AENMLEELRG QQTEHETEIK DLTQLLEKER SILDDIKLSL 540
KDKTKNISAE IIRHEKELEP WDLQLQEKES QIQLAESELS LLEETQAKLK KNVETLEEKI 600
LAKKTHKQEL QDLILDLKKK LNSLKDERSQ GEKNFTSAHL KLKEMQKVLN AHRQRAMEAR 660
SSLSKAQNKS KVLTALSRLQ KSGRINGFHG RLGDLGVIDD SFDVAISTAC PRLDDVVVDT 720
VECAQHCIDY LRKNKLGYAR FILLDRLRQF NLQPISTPEN VPRLFDLVKP KNPKFSNAFY 780
SVLRDTLVAQ NLKQANNVAY GKKRFRVVTV DGKLIDISGT MSGGGNHVAK GLMKLGTNQS 840
DKVDDYTPEE VDKIERELSE RENNFRVASD TVHEMEEELK KLRDHEPDLE SQISKAEMEA 900
DSLASELTLA EQQVKEAEMA YVKAVSDKAQ LNVVMKNLER LRGEYNDLQS ETKTKKEKIK 960
GLQDEIMKIG GIKLQMQNSK VESVCQKLDI LVAKLKKVKS ASKKSGGDVV KFQKLLQNSE 1020
RDVELSSDEL KVIEEQLKHT KLALAENDTN MNETLNLKVE LKEQSEQLKE QMEDMEESIN 1080
EFKSIEIEMK NKLEKLNSLL TYIKSEITQQ EKGLNELSIR DVTHTLGMLD DNKMDSVKED 1140
VKNNQELDQE YRSCETQDES EIKDAETSCD NYHPMNIDET SDEVSRGIPR LSEDELRELD 1200
VELIESKINE LSYYVEETNV DIGVLEEYAR RLAEFKRRKL DLNNAVQKRD EVKEQLGILK 1260
KKRFDEFMAG FNIISMTLKE MYQMITMGGN AELELVDSLD PFSEGVTFSV MPPKKSWRNI 1320
TNLSGGEKTL SSLALVFALH KYKPTPLYVM DEIDAALDFR NVSIVANYIK ERTKNAQFIV 1380
ISLRNNMFEL AQQLVGVYKR DNRTKSTTIK NIDILNRT 1418 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |