CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015074
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rhomboid domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 RHBDD2 
Gene Synonyms/Alias
 RHBDL7 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51APSGLTLKSEALRNWubiquitination[1, 2, 3, 4, 5, 6, 7]
213LSERVALKLDQTFPFubiquitination[2, 6]
230MRRISVFKYVSGSSAubiquitination[1, 3, 5, 6, 7, 8]
246RRAAQSRKLNPVPGSubiquitination[5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [7] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [8] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Golgi apparatus; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 364 AA 
Protein Sequence
MAASGPGCRS WCLCPEVPSA TFFTALLSLL VSGPRLFLLQ QPLAPSGLTL KSEALRNWQV 60
YRLVTYIFVY ENPISLLCGA IIIWRFAGNF ERTVGTVRHC FFTVIFAIFS AIIFLSFEAV 120
SSLSKLGEVE DARGFTPVAF AMLGVTTVRS RMRRALVFGM VVPSVLVPWL LLGASWLIPQ 180
TSFLSNVCGL SIGLAYGLTY CYSIDLSERV ALKLDQTFPF SLMRRISVFK YVSGSSAERR 240
AAQSRKLNPV PGSYPTQSCH PHLSPSHPVS QTQHASGQKL ASWPSCTPGH MPTLPPYQPA 300
SGLCYVQNHF GPNPTSSSVY PASAGTSLGI QPPTPVNSPG TVYSGALGTP GAAGSKESSR 360
VPMP 364 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. 
Interpro
 IPR022764; Peptidase_S54_rhomboid_dom. 
Pfam
 PF01694; Rhomboid 
SMART
  
PROSITE
  
PRINTS