UniProt Accession

 SECY_MYCPN; Q59548 

Genbank Protein ID

 U34795; U00089 

Genbank Nucleotide ID

 AAC43697.1; AAB96295.1 

Protein Name

 Protein translocase subunit SecY 

Protein Synonyms/Alias

  

Gene Name

 secY 

Gene Synonyms/Alias

 MPN_184; MP647 

Created Date

 July 27, 2013 

Organism

 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 

NCBI Taxa ID

 272634 

Lysine Modification

Position	Peptide	Type	References
360	RLAKNFEKSGRFIPG	acetylation	[1]

Reference

 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 

Functional Description

 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity). 

Sequence Annotation

  

Keyword

 Cell membrane; Complete proteome; Membrane; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 477 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0065002; P:intracellular protein transmembrane transport; IEA:HAMAP.
 GO:0006605; P:protein targeting; IEA:HAMAP.
 GO:0043952; P:protein transport by the Sec complex; IEA:HAMAP. 

Interpro

 IPR026593; SecY.
 IPR002208; SecY/SEC61-alpha.
 IPR023201; SecY_su_dom. 

Pfam

 PF00344; SecY 

SMART

  

PROSITE

 PS00755; SECY_1
 PS00756; SECY_2 

PRINTS